{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:13:38Z","timestamp":1791810818788,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We performed acute and chronic studies in healthy and diet\u2010induced obese animals using mouse\u2010specific or monkey\u2010specific dual GLP\u20101R\/GCGR agonists to investigate their effects on food intake, body weight, blood glucose control and insulin secretion. The selective GLP\u20101R agonist liraglutide was used as comparator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The mouse\u2010specific dual agonist and liraglutide were tested in lean wild type, GLP\u20101R knockout and diet\u2010induced obese mice at different doses. A chronic study was performed in DIO mice to investigate the effect on body weight, food consumption and total energy expenditure (TEE) in obese and diabetic monkeys with a focus on body weight and energy intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mouse\u2010specific dual agonist and liraglutide similarly affected glycaemic control. A higher loss in body weight was measured in dual agonist\u2010treated obese mice. The dual agonist significantly enhanced plasma glucose excursion in overnight fed GLP\u20101R\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice, probably reflecting a potent GCGR agonist activity. It increased TEE and enhanced fat and carbohydrate oxidation, while liraglutide produced no effect on TEE. In obese and diabetic monkeys, treatment with the monkey\u2010specific dual agonist reduced total energy intake to 60%\u201070% of baseline TEI during chronic treatment. A decrease in body weight and significant improvement in glucose tolerance was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In DIO mice and non\u2010human primates, dual agonists elicited robust glycaemic control, similar to the marketed GLP\u20101R agonist, while eliciting greater effects on body weight. Results from DIO mice suggest that the increase in TEE is caused not only by increased fat oxidation but also by an increase in carbohydrate oxidation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13212","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T06:28:22Z","timestamp":1529908102000},"page":"1836-1851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Running on mixed fuel\u2010dual agonistic approach of GLP\u20101 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non\u2010human primates"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-307X","authenticated-orcid":false,"given":"Ralf","family":"Elvert","sequence":"first","affiliation":[{"name":"Sanofi\u2010Aventis Deutschland GmbH Frankfurt 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