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While it is well\u2010established that diabetes is associated with an elevated risk of cardiovascular disease and cancer, it has recently been shown that heart failure and cancer may precede, and even contribute to, the development of T2D. In the present review, we have summarized these findings and discuss their potential implications for our understanding of the T2D disease entity, including its treatment and associated increased mortality. We suggest that the existence of a hitherto unrecognized distinct T2D subtype, secondary to heart failure and\/or cancer, may substantially contribute to the excess mortality reported in T2D patients with mild disease. Treatment and clinical care of this subtype needs to be defined separately from the general T2D phenotype.<\/jats:p>","DOI":"10.1111\/dom.13238","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T12:42:09Z","timestamp":1517316129000},"page":"1342-1349","source":"Crossref","is-referenced-by-count":5,"title":["Perspectives on diabetes mortality as the result of residual confounding and reverse causality by common disease"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8639-9117","authenticated-orcid":false,"given":"Anne Cathrine B.","family":"Thuesen","sequence":"first","affiliation":[{"name":"Diabetes and Metabolism, Department of Endocrinology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Vaag","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disease (CVMD) Translational Medicine Unit, Early Clinical Development 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