{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:04:09Z","timestamp":1772910249044,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    Although guidelines recommend strict blood pressure (BP) control in patients with type 2 diabetes mellitus (T2DM) and elevated cardiovascular risk, the long\u2010term effects of this approach are unknown. We investigated the effect of intensive BP control on clinical outcomes in patients with T2DM over 9 years of follow\u2010up. We included Action to Control Cardiovascular Risk in Diabetes \u2010 Blood Pressure participants in the standard glucose control arm who had established cardiovascular disease, chronic kidney disease, were \u226575\u2009years of age or who had a 10\u2010year coronary heart risk \u226515%. Participants were randomized to either intensive (systolic BP\u2009&lt;\u2009120\u2009mm\u2009Hg) or standard (systolic BP\u2009&lt;\u2009140\u2009mm\u2009Hg) BP control for an average of 5 years. Observational follow\u2010up occurred for an average of 4 years thereafter. After an average total follow\u2010up of 9 years, intensive BP control reduced the composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke by 25% (hazard ratio, 0.75; 95% confidence interval, 0.60\u20100.95;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.02). The overall benefit was driven by a reduction in nonfatal myocardial infarction (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.01). In this post\u2010hoc analysis, the benefits of a fixed\u2010duration intensive BP control intervention in patients with T2DM persisted throughout 9 years of follow\u2010up.\n                  <\/jats:p>","DOI":"10.1111\/dom.13248","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T08:06:40Z","timestamp":1518163600000},"page":"1499-1502","source":"Crossref","is-referenced-by-count":38,"title":["Effect of intensive blood pressure control in patients with type 2 diabetes mellitus over 9 years of follow\u2010up: A subgroup analysis of high\u2010risk ACCORDION trial participants"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-1486","authenticated-orcid":false,"given":"Leo F.","family":"Buckley","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine and Department of Pharmacy Services Brigham and Women's Hospital  Boston Massachusettes"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave L.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science Virginia Commonwealth University  Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"George F.","family":"Wohlford","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science Virginia Commonwealth University  Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayanjan S.","family":"Wijesinghe","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science Virginia Commonwealth University  Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice University of Connecticut School of Pharmacy, University of Connecticut  Storrs Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin W.","family":"Van Tassell","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science Virginia Commonwealth University  Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.2169"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw065"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.209"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1366"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0885"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2283"},{"key":"e_1_2_6_10_1","first-page":"S1","article-title":"Standards of medical care in diabetes\u20102017","volume":"40","author":"American Diabetes Association","year":"2017","journal-title":"Diabetes Care"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2334"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030342"},{"key":"e_1_2_6_13_1","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults","author":"Whelton PK","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1722"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007509"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-1756"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.117.003624"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci17-0026"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:17:13Z","timestamp":1761873433000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,2]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/dom.13248"],"URL":"https:\/\/doi.org\/10.1111\/dom.13248","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,2]]}}}