{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T08:46:51Z","timestamp":1792313211399,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Hospital of T\u00fcbingen, Germany"},{"name":"DSM Nutritional Products, Kaiseraugst, Ltd, Switzerland"},{"name":"Deutsches Zentrum f\u00fcr Diabetesforschung"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    We performed the largest randomized, placebo\u2010controlled clinical trial to date (N = 112, 12\u2010week intervention) to investigate the effects and safety of resveratrol supplementation on liver fat content and cardiometabolic risk parameters in overweight and obese and insulin\u2010resistant subjects. At baseline the variability in liver fat content was very large, ranging from 0.09% to 37.55% (median, 7.12%; interquartile range, 3.85%\u201012.94%). Mean (SD) liver fat content was 9.22 (6.85) % in the placebo group and 9.91 (7.76) % in the resveratrol group. During the study liver fat content decreased in the placebo group (\u22120.7%) but not in the resveratrol group (\u22120.03%) (differences between groups:\n                    <jats:italic>P<\/jats:italic>\n                    = .018 for the intention\u2010to\u2010treat [ITT] population; N = 54, resveratrol, N = 54, placebo and\n                    <jats:italic>P<\/jats:italic>\n                    = .0077 for the per protocol [PP] population). No effects of resveratrol supplementation on cardiometabolic risk parameters were observed. Resveratrol supplementation was well tolerated and safe.\n                  <\/jats:p>\n                  <jats:p>In conclusion, these data suggest that resveratrol supplementation is safe and that it does not considerably impact liver fat content or cardiometabolic risk parameters in humans.<\/jats:p>","DOI":"10.1111\/dom.13268","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T01:32:51Z","timestamp":1519695171000},"page":"1793-1797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Effects of resveratrol supplementation on liver fat content in overweight and insulin\u2010resistant subjects: A randomized, double\u2010blind, placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Konstantinos","family":"Kantartzis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bombrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Machann","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Department of Radiology, Section on Experimental Radiology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Schick","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Department of Radiology, Section on Experimental Radiology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Staiger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kunz","sequence":"additional","affiliation":[{"name":"DSM Nutritional Products, Kaiseraugst, Ltd  Kaiseraugst Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotraut","family":"Schoop","sequence":"additional","affiliation":[{"name":"DSM Nutritional Products, Kaiseraugst, Ltd  Kaiseraugst Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lehn\u2010Stefan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Heni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Ulrich","family":"H\u00e4ring","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry University of T\u00fcbingen  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