{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:19:50Z","timestamp":1768007990291,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Boryung Pharmaceutical Co., Ltd., Republic of Korea"},{"name":"Innovative Research Institute for Cell Therapy of the Ministry of Health and Welfare, Republic of Korea","award":["A062260"],"award-info":[{"award-number":["A062260"]}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To study the effects of angiotensin receptor blockers (ARBs) on insulin secretion in hypertensive patients with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A total of 41 patients were enrolled in this open\u2010label, active comparator\u2010controlled, crossover study. After a 2\u2010week run\u2010in period with amlodipine, the participants were assigned to receive either fimasartan (60\u2013120 mg daily) or amlodipine (5\u201310 mg daily) for 16 weeks. Thereafter, they were treated with the other drug for another 16 weeks. Physical examinations and laboratory tests were performed before and after each treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Blood pressure, glycated haemoglobin and oral glucose tolerance test (OGTT) values were similar with each treatment. Fimasartan treatment significantly increased median (range) homeostatic assessment of \u03b2\u2010cell function values (49.9 [22.5\u2013174.4] vs 46.9 [15.6\u2013148.0]), area under the curve of insulin during OGTT (27 284 [9501\u201394 525] vs 26 818 [8112\u201376 704] pmol\/L \u00d7 min), insulinogenic index at 60 minutes (19.7 [3.0\u2013131.2] vs 15.0 [2.4\u2013103.8] pmol\/mmol) and at 120 minutes (19.1 [1.9\u201385.5] vs 12.6 [\u22124.3\u2013178.8] pmol\/mmol) compared with those with amlodipine (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05); however, acute insulin response and insulin resistance indices were similar for both agents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with amlodipine, fimasartan increased late\u2010phase glucose\u2010stimulated insulin secretion in patients with type 2 diabetes and hypertension. This finding suggests that ARBs would be more beneficial in such patients compared with other classes of anti\u2010hypertensives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13282","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T21:22:53Z","timestamp":1521148973000},"page":"1670-1677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fimasartan increases glucose\u2010stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9682-6138","authenticated-orcid":false,"given":"Ye Seul","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Republic of 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