{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:49:29Z","timestamp":1761893369905,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"No funding was received related to the conduct of this study."}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n                    Statins are widely prescribed, yet statin muscle pain limits their use, leading to increased cardiovascular risk. No validated therapy for statin muscle pain exists. The goal of the study was to assess whether metformin was associated with reduced muscle pain. A secondary analysis of data from the ACCORD trial was performed. An ACCORD sub\u2010study assessed patients for muscle cramps and leg\/calve pain while walking, typical non\u2010severe statin muscle pain symptoms. We compared muscle pain between patients using a statin (n\u2009=\u2009445) or both a statin and metformin (n\u2009=\u2009869) at baseline. Overall patient characteristics were balanced between groups. Unadjusted analysis showed fewer reports of muscle cramps (35%) and leg\/calve pain while walking (40%) with statins and metformin compared to statin only (muscle cramps, 42%; leg\/calve pain while walking, 47%). Multivariable regression demonstrated a 22% odds reduction for muscle cramps (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.049) and a 29% odds reduction for leg\/calve pain while walking (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01). Metformin appears to reduce the risk of non\u2010severe statin muscle pain and additional research is needed to confirm the findings and assess metformin's impact on statin adherence and related cardiovascular outcomes.\n                  <\/jats:p>","DOI":"10.1111\/dom.13302","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:06:06Z","timestamp":1522022766000},"page":"1994-1999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metformin's impact on statin\u2010associated muscle symptoms: An analysis of ACCORD study data and research materials from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-5034","authenticated-orcid":false,"given":"Nicholas W.","family":"Carris","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapeutics and Clinical 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R.","family":"Magness","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of South Florida, Perinatal Research Vascular Center Morsani College of Medicine  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambuj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of South Florida, Morsani College of Medicine  Tampa 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