{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:06:52Z","timestamp":1781114812141,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n                    The effects of empagliflozin on cardiorespiratory fitness in patients with type 2 diabetes mellitus (T2DM) and heart failure with reduced ejection fraction (HFrEF) are unknown. In this pilot study we determined the effects of empagliflozin 10\u2009mg\/d for 4\u2009weeks on peak oxygen consumption (VO\n                    <jats:sub>2<\/jats:sub>\n                    ) in 15 patients with T2DM and HFrEF. As an exploratory analysis, we assessed whether there was an interaction of the effects of empagliflozin on peak VO\n                    <jats:sub>2<\/jats:sub>\n                    of loop diuretics. Empagliflozin reduced body weight (\u22121.7\u2009kg;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.031), but did not change peak VO\n                    <jats:sub>2<\/jats:sub>\n                    (from 14.5\u2009mL kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    [12.6\u201017.8] to 15.8 [12.5\u201017.4] mL\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.95). However, patients using loop diuretics (N\u2009=\u20099) demonstrated an improvement, whereas those without loop diuretics (N\u2009=\u20096) experienced a decrease in peak VO\n                    <jats:sub>2<\/jats:sub>\n                    (+0.9 [0.1\u20101.4] vs \u22120.9 [\u22122.1 to \u22120.3] mL\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.001), and peak VO\n                    <jats:sub>2<\/jats:sub>\n                    changes correlated with the baseline daily dose of diuretics (R\u2009=\u2009+0.83;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Empagliflozin did not improve peak VO\n                    <jats:sub>2<\/jats:sub>\n                    in patients with T2DM and HFrEF. However, as a result of exploratory analysis, patients concomitantly treated with loop diuretics experienced a significant improvement in peak VO\n                    <jats:sub>2<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/dom.13309","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T01:18:04Z","timestamp":1522459084000},"page":"2014-2018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of empagliflozin on cardiorespiratory fitness and significant interaction of loop diuretics"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-0527","authenticated-orcid":false,"given":"Salvatore","family":"Carbone","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"},{"name":"Department of Experimental Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Canada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"},{"name":"Kinesiology and Health Science, College of Humanities and Sciences, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley E.","family":"Billingsley","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kadariya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave L.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcome Sciences Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory R.","family":"Trankle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-1486","authenticated-orcid":false,"given":"Leo F.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Department of Pharmacy Service Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshanak","family":"Markley","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Medina de Chazal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanah","family":"Christopher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Buzzetti","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin W.","family":"Van Tassell","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcome Sciences Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Abbate","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029284"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2014.08.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.012"},{"key":"e_1_2_6_7_1","first-page":"2","article-title":"Usefulness of C\u2010reactive protein plasma levels to predict exercise intolerance in patients with chronic systolic heart failure","volume":"117","author":"Canada JM","year":"2015","journal-title":"Am J 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