{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:32Z","timestamp":1791389312715,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T00:00:00Z","timestamp":1525564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Patients with type 2 diabetes have a high risk of cardiovascular disease (CVD). Central obesity has been particularly associated with this risk relationship. We aimed to evaluate waist to height ratio (WHtR) as a predictor of risk in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>WHtR was evaluated as a predictor of the risk of CVD and mortality amongst 11\u2009125 participants with type 2 diabetes in the ADVANCE and ADVANCE\u2010ON studies, and was compared with body mass index (BMI), waist circumference and waist hip ratio (WHR). Primary outcome was a composite of death from CVD, non\u2010fatal myocardial infarction or non\u2010fatal stroke. Secondary outcomes were myocardial infarction, stroke, cardiovascular death and death from any cause. Cox models were used, with bootstrapping to compare associations between anthropometric measures for the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow\u2010up time was 9.0\u2009years. There was a positive association between WHtR and adverse outcomes. The hazard ratio (HR) (confidence interval), per SD higher WHtR, was 1.16 (1.11\u20101.22) for the primary endpoint, with no heterogeneity by sex or region, but a stronger effect in individuals aged 66\u2009years or older. The other 3 anthropometric measurements showed similar associations, although there was evidence that WHtR marginally outperformed BMI and WHR. Based on commonly used BMI cut\u2010points, the equivalent WHtR cut\u2010points were estimated to be 0.55 and 0.6, with no evidence of a difference across subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with diabetes, WHtR is a useful indicator of future adverse risk, with similar effects in different population subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13311","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T01:53:05Z","timestamp":1522461185000},"page":"1903-1910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Use of the waist\u2010to\u2010height ratio to predict cardiovascular risk in patients with diabetes:\n                    <scp>R<\/scp>\n                    esults from the\n                    <scp>ADVANCE\u2010ON<\/scp>\n                    study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3120-0913","authenticated-orcid":false,"given":"Karin","family":"R\u00e5dholm","sequence":"first","affiliation":[{"name":"Division of Community Medicine, Primary Care, Department of Medicine and Health Sciences, Faculty of Health Sciences Link\u00f6ping University, Department of Local Care West, County Council of \u00d6sterg\u00f6tland  Link\u00f6ping Sweden"},{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Chalmers","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Ohkuma","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"},{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-5412","authenticated-orcid":false,"given":"Sanne","family":"Peters","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Poulter","sequence":"additional","affiliation":[{"name":"International Centre for Circulatory Health Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Hamet","sequence":"additional","affiliation":[{"name":"Montreal Diabetes Research Centre Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Harrap","sequence":"additional","affiliation":[{"name":"The University of Melbourne and Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Woodward","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"},{"name":"The George Institute for Global Health University of Oxford  Oxford UK"},{"name":"Department of Epidemiology Johns Hopkins University  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi253"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6428.1401"},{"key":"e_1_2_5_4_1","first-page":"287","article-title":"Central obesity and risk of cardiovascular disease in the Asia Pacific Region","volume":"15","author":"Asia Pacific Cohort Studies Collaboration","year":"2006","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_5_5_1","unstructured":"World Health Organization. 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