{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:31:39Z","timestamp":1782459099436,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health, National Institute on Aging","award":["Intramural Research Programme"],"award-info":[{"award-number":["Intramural Research Programme"]}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n                    Low\u2010calorie sweeteners (LCSs) are widely used for weight control despite limited evidence of their effectiveness and studies linking LCS consumption with incident obesity. We tested the hypothesis that regular LCS consumption is associated with higher postprandial glucose\u2010dependent insulinotropic polypeptide (GIP) secretion, which has been linked to obesity. We used data from participants in the Baltimore Longitudinal Study of Aging who had completed a diet diary, had at least one visit during which they underwent an oral glucose tolerance test (OGTT), and had no diabetes. Of 232 participants, 166 contributed 1, 39 contributed 2, and 27 contributed 3 visits, and 96 (41%) reported using LCS. Plasma OGTT samples were analysed for glucose, insulin and GIP. Fasting glucose, insulin and GIP levels were no different between LCS users and non\u2010users. The association of LCS use with 2\u2010hour OGTT responses after adjustment for covariates was non\u2010significant for glucose (\n                    <jats:italic>P<\/jats:italic>\n                    = .98) and insulin (\n                    <jats:italic>P<\/jats:italic>\n                    = .18), but significant for greater increase in GIP in LCS users (\n                    <jats:italic>P<\/jats:italic>\n                    = .037). Regular consumption of LCSs was associated with greater increases in GIP secretion after food intake, which may potentially lead to weight gain through the lipogenic properties of GIP.\n                  <\/jats:p>","DOI":"10.1111\/dom.13328","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:34:10Z","timestamp":1524530050000},"page":"2282-2285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regular low\u2010calorie sweetener consumption is associated with increased secretion of glucose\u2010dependent insulinotropic polypeptide"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3218-0141","authenticated-orcid":false,"given":"Chee W.","family":"Chia","sequence":"first","affiliation":[{"name":"Intramural Research Programme, National Institute on Aging, National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Shardell","sequence":"additional","affiliation":[{"name":"Intramural Research Programme, National Institute on Aging, National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer S.","family":"Gravenstein","sequence":"additional","affiliation":[{"name":"Intramural Research Programme, National Institute on Aging, National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga D.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Intramural Research Programme, National Institute on Aging, National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Simonsick","sequence":"additional","affiliation":[{"name":"Intramural Research Programme, National Institute on Aging, National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Intramural Research Programme, National Institute on Aging, National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine M.","family":"Egan","sequence":"additional","affiliation":[{"name":"Intramural Research Programme, National Institute on Aging, National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Obesity Federation.https:\/\/www.worldobesity.org\/data\/obesity-data-repository\/. 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