{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:49:32Z","timestamp":1761893372510,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astra Zeneca"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Type 1 diabetes is associated with an increased risk of cardiovascular disease and all\u2010cause mortality. Numerous studies have demonstrated that outcomes for diabetes are improved by intensive glycaemic control, blood pressure control, and treatment of dyslipidaemia in addition to cessation of smoking. The aim of this study was to compare mortalities in individuals with type 1 diabetes with that in non\u2010diabetic individuals, and to investigate the effects of age, gender, glycaemic control, socio\u2010economic status, hypertension, ischaemic heart disease (IHD), smoking status, body mass index (BMI) and dyslipidaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A population\u2010based analysis in Ayrshire and Arran, Scotland included 253\u2009304 non\u2010diabetic individuals and 1324 individuals with type 1 diabetes who were tracked from 2009 to 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with type 1 diabetes had higher mortality rates than non\u2010diabetic individuals (HR, 3.20;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.01), with relative mortality in female individuals with type 1 diabetes being higher than that in males (OR, 2.38 vs 1.52;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.01). Increasing age (HR, 2.37), smoking (HR, 1.85), IHD (HR, 1.62) and hypertension (HR, 1.21) (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.01) increased mortality risk. A hypertensive female with type 1 diabetes and IHD who smoked had an HR of 11.6 compared with a non\u2010smoking, normotensive non\u2010diabetic female without IHD. For a hypertensive male with type 1 diabetes and IHD who smoked, HR was 6.96. BMI\u2009&gt;\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was associated with reduced mortality risk in both non\u2010diabetic (HR, 0.61) and diabetic subjects (HR, 0.40).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirmed that the risk of mortality in individuals with type 1 diabetes remains elevated. Further studies are required to understand how gender affects the disparity in mortality and why obesity appears to be protective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13334","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T01:48:26Z","timestamp":1524534506000},"page":"1965-1971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mortality risk remains higher in individuals with type 1 diabetes: A population\u2010based cohort study (the Ayrshire diabetes follow\u2010up cohort [ADOC])"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-6244","authenticated-orcid":false,"given":"Andrew","family":"Collier","sequence":"first","affiliation":[{"name":"Diabetes Day Centre, NHS Ayrshire and Arran University Hospital Ayr  Ayr UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-9977","authenticated-orcid":false,"given":"Paul J.","family":"Connelly","sequence":"additional","affiliation":[{"name":"Diabetes Day Centre, NHS Ayrshire and Arran University Hospital Ayr  Ayr UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Hair","sequence":"additional","affiliation":[{"name":"Statistics Consultant, NHS Ayrshire and Arran University Hospital Ayr  Ayr UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyall","family":"Cameron","sequence":"additional","affiliation":[{"name":"Primary Care Quality and Development, NHS Ayrshire and Arran Ailsa Hospital  Ayr UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujoy","family":"Ghosh","sequence":"additional","affiliation":[{"name":"AMRI Institute of Diabetes and Hormonal Disorders  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Waugh","sequence":"additional","affiliation":[{"name":"Division of Health Sciences Warwick Medical School  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0862"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5364"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408214"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0082-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.16425"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052187"},{"issue":"1","key":"e_1_2_5_9_1","first-page":"S11","article-title":"Standards of medical care in diabetes 2017","volume":"40","author":"Diabetes Care American Diabetes Association","year":"2017","journal-title":"Diabetes Care"},{"key":"e_1_2_5_10_1","unstructured":"PCA(M)2013)2\u20102013\/14 General Medical Services contract: Scottishwww.sehd.scot.nhs.uk\/pca\/PCA2013(M)02.pdfAccessed November 11 2017."},{"key":"e_1_2_5_11_1","unstructured":"Scottish Government. (Riaghaltus na h\u2010Alba). Statistics: Scottish Index of multiple deprivation.http:\/\/www.scotland.gov.uk\/Topics\/Statististics\/SIMD\/2012Accessed December 1 2017."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2014.09.004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12569"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00986-4"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91342-0"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.04.06.dc05-1433"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1720"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001321"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2388"},{"key":"e_1_2_5_20_1","unstructured":"Department of Health(2011).Start Active Stay Active: A Report on Physical Activity for Health from the Four Home Countries\u2019 Chief Medical Officers.https:\/\/www.gov.uk.government\/publications\/start-active-stay"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01802-2"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69251-9"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.05.011"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000535"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0103"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dcS13-2023"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0b013e318219cd89"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000075"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21181"},{"key":"e_1_2_5_30_1","unstructured":"British Medical Association and NHS Employers. Quality and Outcomes Framework guidance for GMS contract 2009\/10.http:\/\/www.lmc.org.uk\/visageimages\/guidance\/2009\/qofguidance200910mar09.pdfAccessed June 9 2017."},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1625"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3914-7"},{"key":"e_1_2_5_33_1","unstructured":"SIGN Guideline 116: Management of Diabetes.https:\/\/www.sign.ac.uk\/guidelines\/fulltext\/116. Accessed October 12 2017."},{"key":"e_1_2_5_34_1","unstructured":"NICE Guidance on Type 1 Diabetes in Adults.https:\/\/www.nice.org.uk\/guidance\/ng17\/chapter\/1-recommendations. Accessed October 12 2017."}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:57:00Z","timestamp":1761886620000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/dom.13334"],"URL":"https:\/\/doi.org\/10.1111\/dom.13334","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2018,5,29]]},"assertion":[{"value":"2018-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}