{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:18:02Z","timestamp":1790209082253,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T00:00:00Z","timestamp":1528588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Peripheral infusion of glucagon\u2010like peptide\u20101 (GLP\u20101) can affect brain activity in areas involved in the regulation of appetite, including hypothalamic and reward\u2010related brain regions. In contrast, the physiological role of endogenous GLP\u20101 in the central regulation of appetite has hardly been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This was a randomized, cross\u2010over trial that involved 12 healthy volunteers who received an intragastric (ig) glucose (gluc) load, with or without intravenous (iv) exendin9\u201039 (ex9\u201039; specific GLP\u20101 receptor antagonist). Functional magnetic resonance imaging was used to investigate the effect of endogenous GLP\u20101 on resting state functional connectivity (rsFC) between homeostatic and reward\u2010related brain regions. Visual analogue scales were used to rate appetite\u2010related sensations. Blood samples were collected for GI hormone measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Administration of iv\u2010ex9\u201039\/ig\u2010gluc induced a significantly higher rsFC, relative to ig\u2010gluc administration, between the hypothalamus and the left lateral orbitofrontal cortex (OFC) as well as the left amygdala (\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 .001, respectively). Administration of iv\u2010ex9\u201039\/ig\u2010gluc induced a significantly higher rsFC, relative to ig\u2010gluc administration, between the right nucleus accumbens and the right lateral OFC (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Administration of iv\u2010ex9\u201039\/ig\u2010gluc induced a significantly lower rsFC, relative to ig\u2010gluc administration, between the midbrain and the right caudate nucleus (\n                      <jats:italic>P<\/jats:italic>\n                      = .001). Administration of ig\u2010gluc significantly decreased prospective food consumption and increased sensations of fullness compared to pre\u2010infusion baseline (\n                      <jats:italic>P<\/jats:italic>\n                      = .028 and\n                      <jats:italic>P<\/jats:italic>\n                      = .019, respectively); these effects were not present in the iv\u2010ex9\u201039\/ig\u2010gluc condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pilot trial provides preliminary experimental evidence that glucose\u2010induced endogenous GLP\u20101 affects central regulation of appetite by modulating rsFC in homeostatic and reward\u2010related brain regions in healthy lean male participants in a GLP\u20101 receptor\u2010mediated fashion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13369","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T01:49:50Z","timestamp":1527040190000},"page":"2330-2338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Endogenous GLP\u20101 alters postprandial functional connectivity between homeostatic and reward\u2010related brain regions involved in regulation of appetite in healthy lean males: A pilotstudy"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-8812","authenticated-orcid":false,"given":"Anne Christin","family":"Meyer\u2010Gerspach","sequence":"first","affiliation":[{"name":"St. Clara Research Ltd  Basel Switzerland"},{"name":"Department of Chronic Diseases, Metabolism and Ageing, Laboratory for Brain\u2010Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID) Catholic University of Leuven  Leuven 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