{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:28:24Z","timestamp":1790440104503,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine whether non\u2010steroidal mineralocorticoid receptor (MR) antagonists oppose metabolic syndrome\u2010related end\u2010organ, i.e. cardiac, damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In Zucker\n                      <jats:italic>fa\/fa<\/jats:italic>\n                      rats, a rat model of metabolic syndrome, we assessed the effects of the non\u2010steroidal MR antagonist finerenone (oral 2 mg\/kg\/day) on left ventricular (LV) function, haemodynamics and remodelling (using echocardiography, magnetic resonance imaging and biochemical methods).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Long\u2010term (90 days) finerenone modified neither systolic blood pressure nor heart rate, but reduced LV end\u2010diastolic pressure and LV end\u2010diastolic pressure\u2010volume relationship, without modifying LV end\u2010systolic pressure and LV end\u2010systolic pressure\u2010volume relationship. Simultaneously, long\u2010term finerenone reduced both LV systolic and diastolic diameters, associated with reductions in LV weight and LV collagen density, while proteinuria and renal nGAL expression were reduced. Short\u2010term (7 days) finerenone improved LV haemodynamics and reduced LV systolic diameter, without modifying LV diastolic diameter. Moreover, short\u2010term finerenone increased myocardial tissue perfusion and reduced myocardial reactive oxygen species, while plasma nitrite levels, an indicator of nitric oxide (NO) bio\u2010availability, were increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In rats with metabolic syndrome, the non\u2010steroidal MR antagonist finerenone opposed metabolic syndrome\u2010related diastolic cardiac dysfunction and nephropathy. This involved acute effects, such as improved myocardial perfusion, reduced oxidative stress\/increased NO bioavailability, as well as long\u2010term effects, such as modifications in the myocardial structure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13393","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T03:10:34Z","timestamp":1528081834000},"page":"2399-2407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Short\u2010 and long\u2010term administration of the non\u2010steroidal mineralocorticoid receptor antagonist finerenone opposes metabolic syndrome\u2010related cardio\u2010renal dysfunction"],"prefix":"10.1111","volume":"20","author":[{"given":"Marianne","family":"Lachaux","sequence":"first","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan","family":"Barrera\u2010Chimal","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1138 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Nicol","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"R\u00e9my\u2010Jouet","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvanie","family":"Renet","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Dumesnil","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Wecker","sequence":"additional","affiliation":[{"name":"Bruker Biospin MRI GmbH Ettlingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Richard","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kolkhof","sequence":"additional","affiliation":[{"name":"Bayer AG Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Jaisser","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1138 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Ouvrard\u2010Pascaud","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-5704","authenticated-orcid":false,"given":"Paul","family":"Mulder","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1096, FHU\u2010 REMOD\u2010VHF 76000 Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2003.12.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.10.2444"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.683"},{"key":"e_1_2_6_5_1","first-page":"557","article-title":"Individuals' cardiovascular risk profile projected by family doctors and individuals' knowledge of cardiovascular risk factors: a challenge for primary prevention. 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