{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:59:23Z","timestamp":1785459563438,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    The majority of patients with type 2 diabetes do not reach target levels of glycated haemoglobin (HbA1c &lt; 7%). We investigated the prevalence of HbA1c\u2010target achievement and opportunities afforded by lifestyle and pharmacological treatment to increase target achievement. We performed cross\u2010sectional analyses of baseline data from the Diabetes and Lifestyle Cohort Twente\u20101 (DIALECT\u20101). Patients were divided according to (1) HbA1c &lt;53 and \u226553 mmol\/mol (&lt;7%) and (2) non\u2010insulin treatment and tertiles of daily insulin use. We found that 161 (36%) patients achieved the target HbA1c level. Patients with HbA1c \u226553 mmol\/mol had a longer duration of diabetes (13 [8\u201020] vs 9 [4\u201014] years;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001) and more frequently were insulin\u2010users (76% vs 41%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). Patients in the highest tertile of insulin use had a higher body mass index than those in the lowest tertile (35.8 \u00b1 5.5 vs 29.8 \u00b1 5.5 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). Achievement of target HbA1c is low in this type 2 diabetes population. High resistance to pharmacological treatment, paralleled with high body mass index, illustrates that increasing insulin sensitivity through lifestyle intervention is the best opportunity to improve HbA1c target achievement in this real\u2010life population.\n                  <\/jats:p>","DOI":"10.1111\/dom.13399","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T10:14:38Z","timestamp":1528107278000},"page":"2494-2499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Glycaemic control in the diabetes and Lifestyle Cohort Twente: A cross\u2010sectional assessment of lifestyle and pharmacological management on Hba1c target achievement"],"prefix":"10.1111","volume":"20","author":[{"given":"Annis C.","family":"Jalving","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Nephrology ZGT Hospital  Almelo and Hengelo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-7925","authenticated-orcid":false,"given":"Christina M.","family":"Gant","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Nephrology ZGT Hospital  Almelo and Hengelo The Netherlands"},{"name":"Department of Internal Medicine, Division of Nephrology University of Groningen, University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Heleen","family":"Binnenmars","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology University of Groningen, University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabita S.","family":"Soedamah\u2010Muthu","sequence":"additional","affiliation":[{"name":"Center of Research on Psychology in Somatic Diseases (CORPS), Department of Medical and Clinical Psychology Tilburg University  Tilburg The Netherlands"},{"name":"Institute for Food, Nutrition and Health University of Reading  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J. L.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology University of Groningen, University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerjan","family":"Navis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology University of Groningen, University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozewijn D.","family":"Laverman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Nephrology ZGT Hospital  Almelo and Hengelo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.12.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070709"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00220-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/58.4.489"},{"key":"e_1_2_6_8_1","volume-title":"Dutch Dietary Guidelines 2015","author":"Health Council of the Netherlands","year":"2015"},{"key":"e_1_2_6_9_1","volume-title":"Multidisciplinaire Richtlijn Cardiovascular Risicomanagement (Herziening 2011)","author":"Kwaliteitsinstituut voor de Gezondheidszorg CBO and Nederlands Huisartsen Genootschap (NHG)","year":"2011"},{"key":"e_1_2_6_10_1","article-title":"Real\u2010life achievement of lipid\u2010lowering treatment targets in the DIAbetes and LifEstyle Cohort Twente: systemic assessment of pharmacological and nutritional factors","author":"Gant CM","journal-title":"Nutr Diabetes"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-013-0034-y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0352-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33102-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051662"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007165"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30412-6"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:13:39Z","timestamp":1761891219000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,26]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/dom.13399"],"URL":"https:\/\/doi.org\/10.1111\/dom.13399","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,26]]},"assertion":[{"value":"2018-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}