{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:47:03Z","timestamp":1761896823835,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore if clinical effects and hypoglycaemia risks associated with insulin glargine 300\u2009U\/mL (Gla\u2010300) and 100\u2009U\/mL (Gla\u2010100) differed by sulphonylurea and\/or glinide (SU\/G) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A post hoc subgroup analysis of 12\u2010month treatment data from the EDITION Japan 2 trial, a randomized, open\u2010label, phase 3 study of Japanese people with type 2 diabetes receiving once\u2010daily Gla\u2010300\/Gla\u2010100\u2009+\u2009oral antihyperglycaemic drugs. Participants previously receiving SU\/G (+SU\/G) were compared with those not taking SU\/G (\u2010SU\/G). Endpoints included HbA1c, hypoglycaemia and body weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For +SU\/G (n\u2009=\u2009152, 63%), HbA1c was reduced from baseline to month 12 for Gla\u2010300 (8.1% to 7.6%) and Gla\u2010100 (8.2% to 7.8%). For \u2010SU\/G (n\u2009=\u200989, 37%), reductions were 7.8% to 7.4%, and 7.9% to 7.5% for Gla\u2010300 and Gla\u2010100, respectively. A lower annualized rate of hypoglycaemia with Gla\u2010300 versus Gla\u2010100 was observed at night (00:00\u201305:59\u2009hours; p\u2009=\u20090.0001) and any time of day (24\u2009hour; p\u2009=\u20090.0015). Irrespective of the insulin used, the incidence and rate of confirmed (\u22643.9 mmol\/L [\u226470\u2009mg\/dL]) or severe hypoglycaemia appeared higher in +SU\/G versus \u2010SU\/G; overall, a reduced incidence of nocturnal hypoglycaemia, and rate of hypoglycaemia at any time, was observed in \u2010SU\/G versus +SU\/G. In the \u2010SU\/G subgroup, body weight gain differences were observed between Gla\u2010300 and Gla\u2010100 (p\u2009&lt;\u20090.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Participants with prior and continued SU\/G use had similar therapeutic responses with basal insulin but greater risk of hypoglycaemia than those not using SU\/G; hypoglycaemia risk was lower with Gla\u2010300 than Gla\u2010100 in both subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13414","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T03:35:41Z","timestamp":1528688141000},"page":"2541-2550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glycaemic control, hypoglycaemia, and weight change with insulin glargine 300\u2009U\/mL versus insulin glargine 100\u2009U\/mL in Japanese adults with type 2 diabetes: A 12\u2010month comparison by concomitant sulphonylurea and\/or glinide use"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8872-3697","authenticated-orcid":false,"given":"Yasuo","family":"Terauchi","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-3036","authenticated-orcid":false,"given":"Matthew C.","family":"Riddle","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes &amp; Clinical Nutrition, Oregon Health and Science University  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Hirose","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology, Department of Medicine, Toho University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Sanofi  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Sanofi  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Sanofi  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-4003","authenticated-orcid":false,"given":"Geremia B.","family":"Bolli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Internal Medicine and Endocrine and Metabolic Sciences, Perugia University Medical School  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO. Global report on diabetes2016.http:\/\/apps.who.int\/iris\/bitstream\/10665\/204871\/1\/9789241565257_eng.pdf?ua=1. Accessed January 27 2016."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12136"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.726"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12902"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt057"},{"volume-title":"IDF Diabetes Atlas","year":"2015","author":"International Diabetes Federation","key":"e_1_2_6_7_1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2017.03.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12438"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0991"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0990"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12472"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12532"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12618"},{"key":"e_1_2_6_15_1","unstructured":"Japan Diabetes Society. Evidence\u2010based practice guideline for the treatment for diabetes in Japan 2013.http:\/\/www.jds.or.jp\/modules\/en\/index.php?content_id=44. Accessed September 2 2016."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2013.10.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-366"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12567"},{"key":"e_1_2_6_19_1","article-title":"Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study","volume":"354","author":"van Dalem J","year":"2016","journal-title":"BMJ"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1245"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2562-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.9400"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.13463"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03605.x"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.13414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.13414","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:01:26Z","timestamp":1761865286000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,16]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/dom.13414"],"URL":"https:\/\/doi.org\/10.1111\/dom.13414","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2018,7,16]]},"assertion":[{"value":"2018-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}