{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:37:39Z","timestamp":1761917859591,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T00:00:00Z","timestamp":1532217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Patient characteristics associated with hypoglycaemia frequency during insulin glargine 100\u2009U\/mL (Gla\u2010100) titration and clinical outcomes at Week 24 were examined using participant\u2010level data from 16 treat\u2010to\u2010target trials involving individuals with type 2 diabetes mellitus who were inadequately controlled with oral antidiabetes drugs and were initiating Gla\u2010100 (n\u2009=\u20093549). Hypoglycaemia (plasma glucose &lt;3.9\u2009mmol\/L or severe) during the first 8\u2009weeks of titration was stratified by number of events (0, 1\u20103 and \u22654), resulting in 72.5%, 20.6% and 6.9% of participants in each group, respectively. Changes in glycaemia, body weight and insulin dose from baseline to Weeks 12 and 24 were analysed. Hypoglycaemia was more common in participants with lower BMI and fasting C\u2010peptide, and in those undergoing sulfonylurea treatment. Glycaemic outcomes at Week 24 were similar in each hypoglycaemia group, despite the fact that the Week 24 mean daily dose and dose increase for Gla\u2010100 were highest in participants without hypoglycaemia and were lowest in those experiencing \u22654 events. The risk of hypoglycaemia during Gla\u2010100 titration depends mainly on patient characteristics and on sulfonylurea use and may delay dose titration, which apparently has little effect on short\u2010term glycaemic control in a clinical trial setting.<\/jats:p>","DOI":"10.1111\/dom.13450","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:20:29Z","timestamp":1529972429000},"page":"2894-2898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypoglycaemia risk in the first 8 weeks of titration with insulin glargine 100 U\/mL in previously insulin\u2010naive individuals with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9590-9473","authenticated-orcid":false,"given":"Brian M.","family":"Frier","sequence":"first","affiliation":[{"name":"BHF Centre for Cardiovascular Science The Queen's Medical Research Institute, University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Landgraf","sequence":"additional","affiliation":[{"name":"Sanofi  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sanofi US Inc.  Bridgewater New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-4003","authenticated-orcid":false,"given":"Geremia B.","family":"Bolli","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Perugia  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-1238","authenticated-orcid":false,"given":"David R.","family":"Owens","sequence":"additional","affiliation":[{"name":"Diabetes Research Group Cymru, College of Medicine University of Swansea  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,22]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.2337\/dc14-2441"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.18553\/jmcp.2015.21.12.1172"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/j.clinthera.2015.11.011"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.17925\/EE.2014.10.01.23"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1016\/j.diabres.2014.08.003"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1111\/dom.12966"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1016\/j.emc.2013.12.004"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.7326\/0003-4819-147-6-200709180-00178"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1111\/j.1464-5491.2011.03416.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1007\/s12325-017-0592-x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1111\/j.1464-5491.2012.03605.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1080\/03007995.2017.1341868"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1111\/dom.12927"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:59:53Z","timestamp":1761865193000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,22]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/dom.13450"],"URL":"https:\/\/doi.org\/10.1111\/dom.13450","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2018,7,22]]},"assertion":[{"value":"2018-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}