{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:38:23Z","timestamp":1790145503210,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the changes in renal endpoints in type 2 diabetes patients treated with dapagliflozin versus other glucose\u2010lowering medications in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>DARWIN\u2010T2D was a retrospective study conducted at 46 outpatient diabetes clinics in Italy. An automated software collected data on 17 285 patients who received dapagliflozin, glucagon\u2010like peptide\u20101 receptor agonists, dipeptidyl peptidase\u20104 inhibitors, or gliclazide, 6751 of whom had a follow\u2010up visit. We analysed changes in albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients who received dapagliflozin (\n                      <jats:italic>n<\/jats:italic>\n                      = 473) were younger, more obese, and had a poorer glucose control than those who received a comparator (\n                      <jats:italic>n<\/jats:italic>\n                      = 2973). After ~6 months, median (interquartile range) AER declined by 37%, from 19.5 (7.5\u201378.2) to 13.2 (6.5\u201345.0) mg\/g (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) in the dapagliflozin group and did not change in the comparator group. After adjusting for confounders, therapy with dapagliflozin versus comparators was associated with an AER reduction of 26.4 \u00b1 13.1 mg\/g (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.045), and eGFR (mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ) diminished by 1.1 \u00b1 0.5 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.049) in the dapagliflozin group and by 0.6 \u00b1 9.1 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002) in the comparator group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.35 between groups). No patient treated with dapagliflozin versus four patients treated with comparators experienced a doubling of serum creatinine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The antiproteinuric effect of dapagliflozin is confirmed here for the first time by real\u2010world data. Despite a mild decline in eGFR, there was no evidence of clinically relevant worsening in renal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13508","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T03:09:07Z","timestamp":1534993747000},"page":"252-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Effectiveness of dapagliflozin versus comparators on renal endpoints in the real world: A multicentre retrospective study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-2097","authenticated-orcid":false,"given":"Gian Paolo","family":"Fadini","sequence":"first","affiliation":[{"name":"Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7855-8253","authenticated-orcid":false,"given":"Anna","family":"Solini","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Molecular and Critical Area Pathology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Manca","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Penno","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Gatti","sequence":"additional","affiliation":[{"name":"Metabolic Disease Unit, San Gennaro Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Anichini","sequence":"additional","affiliation":[{"name":"Diabetes Unit, Department of Internal Medicine San Jacopo Hospital  Pistoia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5388-0270","authenticated-orcid":false,"given":"Stefano","family":"Del Prato","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-0516","authenticated-orcid":false,"given":"Angelo","family":"Avogaro","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For The DARWIN\u2010T2D 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