{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:02:34Z","timestamp":1794045754170,"version":"4.8.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:00:00Z","timestamp":1538870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate if glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) reduce antipsychotic\u2010associated body weight gain in patients with schizophrenia, when compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed\/EMBASE\/PsycINFO\/Cochrane using the search terms \u2018(antipsychotic and GLP\u20101RA)\u2019. Individual participant data from studies randomizing patients to GLP\u20101RA or control were meta\u2010analysed. The primary outcome was difference in body weight between GLP\u20101RA and control; secondary outcomes included cardio\u2010metabolic variables and adverse drug reactions (ADRs). Multiple linear regression was conducted including sex, age, psychosis severity, metabolic variable, ADRs, and GLP\u20101RA agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three studies (exenatide once\u2010weekly = 2; liraglutide once\u2010daily = 1) provided participant\u2010level data (n = 164, age = 40.0 \u00b1 11.1 years, body weight = 105.8 \u00b1 20.8 kg). After 16.2 \u00b1 4.0 weeks of treatment, body weight loss was 3.71 kg (95% CI = 2.44\u20104.99 kg) greater for GLP\u20101RA versus control (p &lt; 0.001), number\u2010needed\u2010to\u2010treat \u22655% body weight loss = 3.8 (95% CI = 2.6\u20107.2). Waist circumference, body mass index, HbA1c, fasting glucose and visceral adiposity were each significantly lower with GLP\u20101RA. Sex, age, psychosis severity, nausea, any ADR, and GLP\u20101RA agent did not significantly impact outcomes. Body weight loss with GLP\u20101RAs was greater for clozapine\/olanzapine\u2010treated patients (n = 141) than other antipsychotics (n = 27) (4.70 kg, 95% CI = 3.13\u20106.27 vs. 1.5 kg, 95% CI = \u22121.47\u20104.47) (p &lt; 0.001). Nausea was more common with GLP\u20101RAs than control (53.6% vs. 27.5%, p = 0.002, number\u2010needed\u2010to\u2010harm = 3.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GLP\u20101RAs are effective and tolerable for antipsychotic\u2010associated body weight gain, particularly clozapine\/olanzapine\u2010treated patients. With few included patients, further studies are required before making routine use recommendations for GLP\u20101RAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13522","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T22:25:19Z","timestamp":1536186319000},"page":"293-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Glucagon\u2010like peptide\u20101 receptor agonists for antipsychotic\u2010associated cardio\u2010metabolic risk factors: A systematic review and individual participant data meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-9216","authenticated-orcid":false,"given":"Dan","family":"Siskind","sequence":"first","affiliation":[{"name":"Metro South Addiction and Mental Health Service  Brisbane Australia"},{"name":"School of Medicine University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-9946","authenticated-orcid":false,"given":"Margaret","family":"Hahn","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health  Toronto Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph U.","family":"Correll","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Northwell Health The Zucker Hillside Hospital  Glen Oaks New York"},{"name":"Hofstra Northwell School of Medicine, Department of Psychiatry and Molecular Medicine  Hempstead New York"},{"name":"Department of Child and Adolescent Psychiatry Charit\u00e9 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Fink\u2010Jensen","sequence":"additional","affiliation":[{"name":"Psychiatric Centre Copenhagen, Rigshospitalet, Mental Health Services \u2013 Capital Region of Denmark  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W.","family":"Russell","sequence":"additional","affiliation":[{"name":"School of Medicine University of Queensland  Brisbane Australia"},{"name":"Department of Endocrinology, Princess Alexandra Hospital  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaj","family":"Bak","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Schizophrenia Research &amp; Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Centre Glostrup University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian V.","family":"Broberg","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Schizophrenia Research &amp; Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Centre Glostrup University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Larsen","sequence":"additional","affiliation":[{"name":"Psychiatric Centre Copenhagen, Rigshospitalet, Mental Health Services \u2013 Capital Region of Denmark  Copenhagen Denmark"},{"name":"Novo Nordisk A\/S, Research and Development  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelle L.","family":"Ish\u00f8y","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Schizophrenia Research &amp; 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