{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:09:39Z","timestamp":1771103379801,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001509","name":"Royal Society of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Current knowledge of biomarkers of intra\u2010pancreatic fat deposition (IFD) is limited. We aimed to analyse comprehensively body composition and insulin traits as biomarkers of IFD in healthy normoglycaemic individuals as well as in individuals with new\u2010onset prediabetes or diabetes after acute pancreatitis (NODAP). A total of 29 healthy individuals and 34 individuals with NODAP took part in this cross\u2010sectional study. The studied biomarkers belonged to the following domains: body composition (anthropometric and MRI\u2010derived variables); indices of insulin secretion; indices of insulin sensitivity; incretins and related peptides; and pancreatitis\u2010related factors. All MRI\u2010derived variables (including IFD) were measured using\n                    <jats:sc>ImageJ<\/jats:sc>\n                    software. Univariate and step\u2010wise regression analyses were conducted to determine variables that best explained variance in IFD. Visceral fat volume and oxyntomodulin were the best biomarkers of IFD in normoglycaemic healthy individuals, contributing to 64% variance. The Raynaud index was the best biomarker of IFD in individuals with NODAP, contributing to 20% variance. Longitudinal studies are warranted to investigate the cause and effect relationship between oxyntomodulin and IFD in healthy individuals, as well as insulin sensitivity and IFD in individuals with NODAP.\n                  <\/jats:p>","DOI":"10.1111\/dom.13523","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T22:51:01Z","timestamp":1536187861000},"page":"417-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Comprehensive analysis of body composition and insulin traits associated with intra\u2010pancreatic fat deposition in healthy individuals and people with new\u2010onset prediabetes\/diabetes after acute pancreatitis"],"prefix":"10.1111","volume":"21","author":[{"given":"Ruma G.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine University of Auckland  Auckland New 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