{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:03:43Z","timestamp":1788264223248,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sanofi-Aventis Deutschland GmbH"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>For patients with type 2 diabetes mellitus (T2DM) and inadequate glycaemic control, addition of basal insulin is recommended, but titration and optimization of basal insulin therapy in primary care is not well understood. We conducted an observational trial in 2470 patients with T2DM who initiated insulin glargine 100 U\/L (Gla\u2010100) on top of oral antidiabetic drugs. Physicians were free to choose either a \u201cDavies,\u201d \u201cFritsche\u201d or \u201cindividual\u201d titration algorithm. We found that fasting blood glucose (FBG) and glycated haemoglobin (HbA1c) levels were effectively reduced by Gla\u2010100; 65.9% of patients achieved the primary endpoint (FBG \u22646.1 mmol\/L (110 mg\/dL) or an individual HbA1c target). There were no significant differences in efficacy and safety between the algorithms used. The mean FBG decreased by 3.2 mmol\/L (59 mg\/dL) over 12 months, while the mean HbA1c decreased by 15.3 mmol\/mol (1.4%)%. From a starting dose of 11.7 U\/d, the Gla\u2010100 dosage was 22.8 U\/d at 12 months, with similar values in each group. Rates of hypoglycaemia were low and did not differ by titration algorithm. We conclude that Gla\u2010100 was effective at reducing FBG and HbA1c, independent of the titration algorithm, but observed that algorithms were inconsistently applied in clinical practice.<\/jats:p>","DOI":"10.1111\/dom.13535","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T08:19:18Z","timestamp":1537258758000},"page":"439-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Titration and optimization trial for the initiation of insulin glargine 100 U\/mL in patients with inadequately controlled type 2 diabetes on oral antidiabetic drugs"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-7310","authenticated-orcid":false,"given":"Jochen","family":"Seufert","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II, Faculty of Medicine Medical Centre \u2013 University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Medical Department IV University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Pscherer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Sophien\u2010 and Hufeland\u2010Hospital  Weimar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Anderten","sequence":"additional","affiliation":[{"name":"Anderten\u2010Krok &amp; Partner  Hildesheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Borck","sequence":"additional","affiliation":[{"name":"Sanofi\u2010Aventis Deutschland GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Pegelow","sequence":"additional","affiliation":[{"name":"Sanofi\u2010Aventis Deutschland GmbH  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bramlage","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Preventive Medicine  Cloppenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pfohl","sequence":"additional","affiliation":[{"name":"Medical Department I Evang. Bethesda\u2010Hospital  Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.21.2005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_7_4_1","unstructured":"Bundes\u00e4rztekammerKBK Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften.Nationale Versorgungs Leitlinie Therapie des Typ\u20102\u2010Diabetes\u2013 Langfassung 1st ed. Version 4. (Last modified: November 2014).2013.www.deutsche\u2010diabetes\u2010gesellschaft.de\/fileadmin\/Redakteur\/Leitlinien\/Evidenzbasierte_Leitlinien\/NVL_Typ\u20102_Therapie\u2010lang_Apr_2014.pdf. 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