{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:33:00Z","timestamp":1789403580151,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014389","name":"Amarin Pharma, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014389","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine whether high triglycerides (TG) in the presence of statin\u2010controlled LDL\u2010C influence the risk of cardiovascular disease (CVD) among patients with diabetes in real\u2010world clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We identified adults with diabetes from the Southern California and Pacific Northwest regions of Kaiser Permanente. We included patients undergoing statin therapy with LDL\u2010C from 40\u2010100 mg\/dL who were not undergoing other lipid\u2010lowering therapies and had a prior diagnosis of atherosclerotic CVD or at least one other CVD risk factor. We grouped patients into high TG (200\u2010499 mg\/dL; n = 5542) or normal TG (&lt;150 mg\/dL, n = 22 411) from January 2010 through December 2016 to compare incidence rates and rate ratios of first non\u2010fatal myocardial infarction (MI), non\u2010fatal stroke, unstable angina and coronary revascularization. We adjusted multivariable analyses for age, sex, race\/ethnicity, smoking status, blood pressure, HbA1c, serum creatinine, presence of ischaemic heart disease and study site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adjusted rate ratios for the four outcomes were all statistically significantly different. The incidence rate for non\u2010fatal MI was 30% higher in the high TG group (rate ratio, 1.30; 95% CI, 1.08\u20101.58;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006). The rate was 23% higher for non\u2010fatal stroke (1.23, 1.01\u20101.49,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.037), 21% higher for coronary revascularization (rate ratio, 1.21; 95% CI, 1.02\u20101.43;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.027) and was, non\u2010significantly, 33% higher for unstable angina (rate ratio, 1.33; 95% CI, 0.87\u20102.03;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.185).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite statin\u2010controlled LDL\u2010C levels, CV events were greater among patients with diabetes and high TG levels. Because we controlled for cardiometabolic risk factors, it is likely that the difference in TG levels contributed to the excess risk observed in patients with high TGs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13537","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T01:45:01Z","timestamp":1537235101000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Increased residual cardiovascular risk in patients with diabetes and high versus normal triglycerides despite statin\u2010controlled LDL cholesterol"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7563-6236","authenticated-orcid":false,"given":"Gregory A.","family":"Nichols","sequence":"first","affiliation":[{"name":"Kaiser Permanente Center for Health Research  Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sephy","family":"Philip","sequence":"additional","affiliation":[{"name":"Amarin Pharma Inc.  Bedminster New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Southern California  Pasadena California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig B.","family":"Granowitz","sequence":"additional","affiliation":[{"name":"Amarin Pharma Inc.  Bedminster New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Fazio","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University  Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.2337\/dc18-Sint01","article-title":"Standards of medical care in diabetes\u2010\u20102018","volume":"41","author":"American Diabetes Association","year":"2018","journal-title":"Diabetes Care"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.03.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.08.039"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.713438"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.038"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.04.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.544"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004229"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.04.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP171764.APPGL"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.05.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00470"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008740"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.13063\/2327-9214.1049"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2383"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.1201"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318796989"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.048"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-012-2320-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.7.1333"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1213829"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-332-OR"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-014-0135-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001282"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1958"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199604000-00014"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.637793"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145615.33955.83"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107579"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300955"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67667-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22692"},{"key":"e_1_2_7_35_1","unstructured":"ClinicalTrials.gov.Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Riak PatienTs With Hypertriglyceridemia (STRENGTH). 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