{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:11:02Z","timestamp":1790655062353,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Princess Alexandra Hospital Research Support Scheme"},{"name":"Pathology Queensland"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether mineralocorticoid (MC) antagonism enhances brown adipose tissue (BAT) function in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In a randomized double\u2010blind, cross\u2010over designed trial, 10 healthy adults (two men, eight women) underwent 2 weeks of spironolactone (100 mg\/d) treatment and placebo, with an intervening 2\u2010week wash\u2010out period. BAT function was assessed in response to cooling and to a mixed meal. Metabolic activity was measured by fluoro\u2010deoxyglucose (FDG) uptake (maximal standardized uptake value, SUV\n                      <jats:sub>max<\/jats:sub>\n                      ) using PET\u2010CT. Thermogenic activity was measured by skin temperatures overlying supraclavicular (SCL) BAT depots using infrared thermography. Postprandial metabolism was measured by energy production rate (EPR) and lipid synthesis using indirect calorimetry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During cooling, BAT metabolic activity (SUV 6.30 \u00b1 2.16 vs 3.98 \u00b1 1.34;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) and volume (54.9 \u00b1 22.8 vs 21.6 \u00b1 11.8 cm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) were significantly higher, and mean SCL temperature decreased by a smaller degree (\u22120.3\u00b0C\u00b0\u00b1 0.2\u00b0C vs \u22120.9\u00b0C \u00b1 0.2\u00b0C;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.05) with spironolactone treatment. A mixed meal increased SCL temperature and EPR. The postprandial rise in SCL temperature (+0.4\u00b0C \u00b1 0.1\u00b0C vs +0.1\u00b0C \u00b1 0.1\u00b0C;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) but not in EPR was greater during spironolactone treatment. Postprandial lipid synthesis occurred in three participants with placebo but in none with spironolactone treatment (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MC antagonism enhanced human BAT function in response to cooling and to a meal during which lipid synthesis was suppressed. As postprandial EPR comprises energy dissipated as heat and energy required to store nutrients, the reduction in lipid synthesis during MC antagonism is a probable consequence of concurrent stimulation of BAT thermogenesis. The shift in energy usage from storage to heat dissipation indicates that MC antagonists may have therapeutic benefit for obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13539","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T01:18:29Z","timestamp":1537233509000},"page":"509-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo\u2010controlled cross\u2010over study"],"prefix":"10.1111","volume":"21","author":[{"given":"Moe","family":"Thuzar","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Princess Alexandra Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland and Translational Research Institute  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikiat Phillip","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging Princess Alexandra Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland and Translational Research Institute  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goce","family":"Dimeski","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology Princess Alexandra Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland and Translational Research Institute  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stowasser","sequence":"additional","affiliation":[{"name":"Endocrine Hypertension Research Centre Princess Alexandra Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland and Translational Research Institute  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-9588","authenticated-orcid":false,"given":"Ken K. Y.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Princess Alexandra Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland and Translational Research Institute  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.07.020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1733"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0450"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3280108e6f"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2013.09.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002505"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000231338.41548.fc"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.177"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-1217"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0513"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3891"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67803"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1915"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870240"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.4.E640"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-245415"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13157"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-6540-1_3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.253"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0240"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.07.014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12167"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(88)90110-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.2.628"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0869"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60433"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4213"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0627"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68993"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037703"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1260434"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2008.03.017"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320340049034"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00982.x"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:51:44Z","timestamp":1761875504000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,14]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/dom.13539"],"URL":"https:\/\/doi.org\/10.1111\/dom.13539","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,14]]},"assertion":[{"value":"2018-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}