{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:49:11Z","timestamp":1788997751303,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P30DK111024\u201001"],"award-info":[{"award-number":["1P30DK111024\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["1P30DK111024\u201001UL1"],"award-info":[{"award-number":["1P30DK111024\u201001UL1"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["TR001082UL1RR025008"],"award-info":[{"award-number":["TR001082UL1RR025008"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The use of incretin\u2010based therapy, rather than or complementary to, insulin therapy is an active area of research in hospitalized patients with type 2 diabetes (T2D). We determined the glycaemic efficacy and safety of linagliptin compared to a basal\u2010bolus insulin regimen in hospitalized surgical patients with T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective open\u2010label multicentre study randomized T2D patients undergoing non\u2010cardiac surgery with admission blood glucose (BG) of 7.8 to 22.2 mmol\/L who were under treatment with diet, oral agents or total insulin dose (TDD) \u2264 0.5 units\/kg\/day to either linagliptin (n = 128) daily or basal\u2010bolus (n = 122) with glargine once daily and rapid\u2010acting insulin before meals. Both groups received supplemental insulin for BG &gt; 7.8 mmol\/L. The primary endpoint was difference in mean daily BG between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean daily BG was higher in the linagliptin group compared to the basal\u2010bolus group (9.5 \u00b1 2.6 vs 8.8 \u00b1 2.3 mmol\/L\/dL,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03) with a mean daily BG difference of 0.6 mmol\/L (95% confidence interval 0.04, 1.2). In patients with randomization BG &lt; 11.1 mmol\/L (63% of cohort), mean daily BG was similar in the linagliptin and basal\u2010bolus groups (8.9 \u00b1 2.3 vs 8.7 \u00b1 2.3 mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.43); however, patients with BG \u2265 11.1 mmol\/L who were treated with linagliptin had higher BG compared to the basal\u2010bolus group (10.9 \u00b1 2.6 vs 9.2 \u00b1 2.2 mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Linagliptin resulted in fewer hypoglycaemic events (1.6% vs 11%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001; 86% relative risk reduction), with similar supplemental insulin and fewer daily insulin injections (2.0 \u00b1 3.3 vs 3.1 \u00b1 3.3,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) compared to the basal\u2010bolus group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For patients with T2D undergoing non\u2010cardiac surgery who presented with mild to moderate hyperglycaemia (BG &lt; 11.1 mmol\/L), daily linagliptin is a safe and effective alternative to multi\u2010dose insulin therapy, resulting in similar glucose control with lower hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13587","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T03:04:26Z","timestamp":1542683066000},"page":"837-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Glycaemic efficacy and safety of linagliptin compared to a basal\u2010bolus insulin regimen in patients with type 2 diabetes undergoing non\u2010cardiac surgery: A multicentre randomized clinical trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Priyathama","family":"Vellanki","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism and Lipids, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Rasouli","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes Department of Medicine, University of 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