{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:15:50Z","timestamp":1779358550861,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify factors associated with achievement of glycated haemoglobin A1c (HbA1c) target at 24 weeks after commencing basal insulin therapy in individuals with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Post\u2010hoc<\/jats:italic>\n                      pooled analysis of 16 randomized, treat\u2010to\u2010target trials involving individuals with T2DM inadequately controlled with oral anti\u2010hyperglycaemic drugs (n = 3415) initiated on once\u2010daily insulin glargine 100 U\/mL (Gla\u2010100). Clinical outcomes were assessed by HbA1c response at 24 weeks and individuals were classified as \u201cgood responders\u201d with HbA1c &lt;7.0% (&lt;53 mmol\/mol) or as \u201cpoor responders\u201d with HbA1c \u22657.0% (\u226553 mmol\/mol). Univariable and multivariable stepwise logistic regression analyses were performed to identify predictive factors for attaining HbA1c &lt;7.0%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lower levels of baseline HbA1c, fasting plasma glucose (FPG) and post\u2010prandial plasma glucose (PPG), higher body mass index (BMI), shorter diabetes duration and male sex were associated with a good glycaemic response, but not age or baseline C\u2010peptide levels. Gla\u2010100 dose (U\/kg) was highest in the poor\u2010responder group, which had the fewest hypoglycaemia episodes. Univariable analysis for achievement of HbA1c &lt;7.0% confirmed these observations. Multivariable analysis retained baseline HbA1c, body weight, BMI, sex, 2\u2010hours PPG and diabetes duration as predictors of a good response. Continued use of sulfonylureas, hypoglycaemia and change in body weight were indicative of poor response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Baseline HbA1c was the strongest determinant for achieving target HbA1c &lt;7.0% by supplementary Gla\u2010100 therapy, while sex and BMI were also useful indicators. However, age and C\u2010peptide levels at baseline did not predict glycaemic response to the introduction of basal insulin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13607","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T03:48:41Z","timestamp":1544068121000},"page":"321-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Commencing insulin glargine 100 U\/mL therapy in individuals with type 2 diabetes: Determinants of achievement of HbA1c goal less than 7.0%"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-1238","authenticated-orcid":false,"given":"David R.","family":"Owens","sequence":"first","affiliation":[{"name":"Swansea University Diabetes Research Group Cymru, College of Medicine  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-7164","authenticated-orcid":false,"given":"Wolfgang","family":"Landgraf","sequence":"additional","affiliation":[{"name":"Sanofi  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9590-9473","authenticated-orcid":false,"given":"Brian M.","family":"Frier","sequence":"additional","affiliation":[{"name":"The Queen's Medical Research Institute University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sanofi US  Bridgewater New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip D.","family":"Home","sequence":"additional","affiliation":[{"name":"Department of Medical School, Institute of Cellular Medicine, Diabetes Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-2725","authenticated-orcid":false,"given":"Luigi","family":"Meneghini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrinology University of Texas Southwestern Medical Center and Parkland Health and Hospital System  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-4003","authenticated-orcid":false,"given":"Geremia B.","family":"Bolli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Perugia School of Medicine  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/CS-2017-0153"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"S1","article-title":"Standards of medical care in diabetes \u2013 2018","volume":"41","author":"American Diabetes Association","year":"2018","journal-title":"Diabetes Care"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0033"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2858"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13132"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.02.034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.11.028"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2014.05.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12966"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2413"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01665.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1171"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40842-018-0059-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12072"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1329"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13179"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5444"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3512-0"},{"key":"e_1_2_7_20_1","first-page":"S35","article-title":"Association of fasting C\u2010peptide levels with glycaemic efficacy and risk of hypoglycaemia in people with type 2 diabetes commencing insulin glargine 100 U\/ml","volume":"60","author":"Owens DR","year":"2017","journal-title":"Diabetologia"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.722989"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.786692"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13156"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:23:08Z","timestamp":1761888188000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/dom.13607"],"URL":"https:\/\/doi.org\/10.1111\/dom.13607","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,10]]},"assertion":[{"value":"2018-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}