{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:22:29Z","timestamp":1791793349590,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>The aim was to assess, in a randomized, double\u2010blinded, placebo\u2010controlled trial, the efficacy of diacerein, an anti\u2010inflammatory drug, in improving liver fibrosis and steatosis in patients with type 2 diabetes and non\u2010alcoholic fatty liver disease (NAFLD). Sixty\u2010nine diabetic patients with NAFLD were randomized to 24\u2010month treatment with placebo (35 patients) or diacerein 100\u2009mg\/day (34 patients). Liver stiffness and steatosis were assessed by transient elastography (Fibroscan\u00ae) at baseline, and 12 and 24\u2009months of follow\u2010up. The primary outcome was the difference in mean liver stiffness and steatosis changes during treatment. Adjusted differences in mean changes on intention\u2010to\u2010treat analyses were estimated by generalized repeated\u2010measures mixed\u2010effects regressions. Diacerein significantly reduced liver stiffness in contrast to placebo by 1.6 kPa (95% CI: \u20132.6 to \u22120.5 kPa; p\u2009=\u20090.003), whereas no significant difference in mean changes in liver steatosis was observed. The reduction in liver stiffness was already evident at the 12\u2010month examination, and accentuated at the 24\u2010month examination. Eight patients reduced liver fibrosis stage during treatment, seven of whom were in the diacerein group (p\u2009=\u20090.020). In conclusion, a 2\u2010year treatment with diacerein significantly reduced liver fibrosis in diabetic patients with NAFLD.<\/jats:p>","DOI":"10.1111\/dom.13643","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T03:04:21Z","timestamp":1548644661000},"page":"1266-1270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of diacerein in reducing liver steatosis and fibrosis in patients with type 2 diabetes and non\u2010alcoholic fatty liver disease: A randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Nathalie C.","family":"Leite","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca B.","family":"Viegas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane A.","family":"Villela\u2010Nogueira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda O.","family":"Carlos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia 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