{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:53:50Z","timestamp":1789944830428,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess amoxicillin\u2010clavulanate (AMC) for the oral therapy of diabetic foot infections (DFIs), especially for diabetic foot osteomyelitis (DFO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort analysis among 794 DFI episodes, including 339 DFO cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median duration of antibiotic therapy after surgical debridement (including partial amputation) was 30\u2009days (DFO, 30\u2009days). Oral AMC was prescribed for a median of 20\u2009days (interquartile range, 12\u201030\u2009days). The median ratio of oral AMC among the entire antibiotic treatment was 0.9 (interquartile range, 0.7\u20101.0). After a median follow\u2010up of 3.3 years, 178 DFIs (22%) overall recurred (DFO, 75; 22%). Overall, oral AMC led to 74% remission compared with 79% with other regimens (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2010test;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.15). In multivariate analyses and stratified subgroup analyses, oral AMC resulted in similar clinical outcomes to other antimicrobial regimens, when used orally from the start, after an initial parenteral therapy, or when prescribed for DFO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral AMC is a reasonable option when treating patients with DFIs and DFOs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13651","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T07:00:02Z","timestamp":1549350002000},"page":"1483-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Oral amoxicillin\u2010clavulanate for treating diabetic foot infections"],"prefix":"10.1111","volume":"21","author":[{"given":"Karim","family":"Gariani","sequence":"first","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"},{"name":"Service of Diabetology and Endocrinology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lebowitz","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"},{"name":"Service of General Internal Medicine Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kressmann","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"von Dach","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Sendi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology University Hospital Basel  Basel Switzerland"},{"name":"Department of Orthopaedics and Traumatology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Waibel","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery Balgrist University Hospital  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Berli","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery Balgrist University Hospital  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Huber","sequence":"additional","affiliation":[{"name":"Pharmacology Balgrist University Hospital  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Lipsky","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"},{"name":"Department of Medicine University of Washington  Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5552-0973","authenticated-orcid":false,"given":"Ilker","family":"U\u00e7kay","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"},{"name":"Infectiology Balgrist University Hospital  Zurich 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