{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:46:40Z","timestamp":1768535200477,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009881","name":"Juvenile Diabetes Research Foundation Canada","doi-asserted-by":"publisher","award":["17\u20102013\u2010312"],"award-info":[{"award-number":["17\u20102013\u2010312"]}],"id":[{"id":"10.13039\/100009881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the relationship between normal plasma uric acid (PUA) levels, renal haemodynamic function, arterial stiffness and plasma renin and aldosterone over a wide range of type 1 diabetes (T1D) durations in adolescents, young adults and older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>PUA, glomerular filtration rate (GFR), effective renal plasma flow (ERPF), vascular stiffness parameters (aortic augmentation index [AIx], carotid AIx, carotid femoral pulse wave velocity [cfPWV]), and plasma renin and aldosterone were measured during a euglycaemic clamp in people with T1D: 27 adolescents (mean\u2009\u00b1\u2009SD age 16.8\u2009\u00b1\u20091.9 years), 52 young adults (mean\u2009\u00b1\u2009SD age 25.6\u2009\u00b1\u20095.5 years) and 66 older adults (mean\u2009\u00b1\u2009SD age 65.7\u2009\u00b1\u20097.5 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PUA was highest in patients with the longest T1D duration: 197\u2009\u00b1\u200944 \u03bcmol\/L in adolescents versus 264\u2009\u00b1\u200982 \u03bcmol\/L in older adults (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.001). Higher PUA correlated with lower GFR only in older adults, even after correcting for age, glycated haemoglobin and sex (\u03b2\u2009=\u2009\u22122.12\u2009\u00b1\u20090.56;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0003), but not in adolescents or young adults. Higher PUA correlated with lower carotid AIx (\u03b2\u2009=\u2009\u22121.90,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) in adolescents. In contrast, PUA correlated with higher cfPWV (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.02) and higher plasma renin (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) in older adults with T1D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The relationship between higher PUA with lower GFR, increased arterial stiffness and renin angiotensin aldosterone system (RAAS) activation was observed only in older adults with longstanding T1D. T1D duration may modify the association between PUA, renal haemodynamic function and RAAS activation, leading to renal vasoconstriction and ischaemia. Further work must determine whether pharmacological PUA\u2010lowering prevents or reverses injurious haemodynamic and neurohormonal sequelae of longstanding T1D, thereby improving clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13665","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T23:52:54Z","timestamp":1550101974000},"page":"1388-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between uric acid, renal haemodynamics and arterial stiffness over the natural history of type 1 diabetes"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1805-9994","authenticated-orcid":false,"given":"Yuliya","family":"Lytvyn","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Toronto General Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-2947","authenticated-orcid":false,"given":"Petter","family":"Bjornstad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology University of Colorado School of Medicine  Aurora Colorado"},{"name":"Department of Medicine, Division of Nephrology University of Colorado School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Lovshin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Toronto General Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve","family":"Boulet","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesta","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Toronto General Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Toronto General Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Cham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Toronto General Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif E.","family":"Lovblom","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-653X","authenticated-orcid":false,"given":"Alanna","family":"Weisman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism, Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary A.","family":"Keenan","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Brent","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, Department of Medicine University of Toronto  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narinder","family":"Paul","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging, Division of Cardiothoracic Radiology University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Bril","sequence":"additional","affiliation":[{"name":"Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine University Health Network, 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