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This has been ascribed, in part, to haemodynamic changes, body weight reduction and several possible effects on myocardial, endothelial and tubulo\u2010glomerular functions, as well as to reduced glucotoxicity. This review evaluates evidence that an effect of SGLT2 inhibitors to lower uric acid may also contribute to reduced cardio\u2010renal risk.<\/jats:p>\n                  <jats:p>Chronically elevated circulating uric acid concentrations are associated with increased risk of hypertension, CV disease and chronic kidney disease (CKD). The extent to which uric acid contributes to these conditions, either as a cause or an aggravating factor, remains unclear, but interventions that reduce urate production or increase urate excretion in hyperuricaemic patients have consistently improved cardio\u2010renal prognoses. Uric acid concentrations are often elevated in type 2 diabetes, contributing to the \u201cmetabolic syndrome\u201d of CV risk. Treating type 2 diabetes with an SGLT2 inhibitor increases uric acid excretion, reduces circulating uric acid and improves parameters of CV and renal function. This raises the possibility that the lowering of uric acid by SGLT2 inhibition may assist in reducing adverse CV events and slowing progression of CKD in type 2 diabetes. SGLT2 inhibition might also be useful in the treatment of gout and gouty arthritis, especially when co\u2010existent with diabetes.<\/jats:p>","DOI":"10.1111\/dom.13670","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T07:14:33Z","timestamp":1550128473000},"page":"1291-1298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Uric acid and the cardio\u2010renal effects of SGLT2 inhibitors"],"prefix":"10.1111","volume":"21","author":[{"given":"Clifford J.","family":"Bailey","sequence":"first","affiliation":[{"name":"School of Life and Health Sciences Aston University  Birmingham 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