{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:13:04Z","timestamp":1761873184628,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK105379, DK083554, DK101991"],"award-info":[{"award-number":["DK105379, DK083554, DK101991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,6]]},"abstract":"\n Patients who have undergone gastric bypass surgery (GB) have enhanced postprandial hyperinsulinaemia and a greater incretin effect is apparent. In the present study, we sought to determine the effect of vagal activation, a neural component of the enteroinsular axis, on postprandial glucose metabolism in patients with and without hypoglycaemia after GB. Seven patients with documented post\u2010GB hypoglycaemia, seven asymptomatic patients without hypoglycaemia post\u2010GB, and 10 weight\u2010matched non\u2010surgical controls with normal glucose tolerance were recruited. Blood glucose, and islet hormone and incretin secretion were compared during mixed meal tolerance tests (MMTs) with and without prior sham\u2010feeding on two separate days. Sham feeding preceding the MMT caused a more rapid increase in prandial blood glucose levels but lowered overall glycaemia in all three groups (\n P<\/jats:italic>\n \u2009<\u20090.05). Sham feeding had a similar effect to increase early (\n P<\/jats:italic>\n \u2009<\u20090.05), but not overall, meal\u2010induced insulin secretion in the three groups. Prandial glucagon concentrations were significantly greater in the GB groups, and sham feeding accentuated this response (\n P<\/jats:italic>\n \u2009<\u20090.05). The effect of vagal activation on prandial glucose and islet\u2010cell function is preserved in patients who have undergone GB, in those both with and without hypoglycaemia.\n <\/jats:p>","DOI":"10.1111\/dom.13676","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T06:20:24Z","timestamp":1550643624000},"page":"1513-1517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycaemia"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-739X","authenticated-orcid":false,"given":"Marzieh","family":"Salehi","sequence":"first","affiliation":[{"name":"Department of Medicine University of Cincinnati College of Medicine Cincinnati Ohio"},{"name":"Division of Diabetes University of Texas at San Antonio San Antonio Texas"},{"name":"Bartter Research Unit, Audie Murphy Hospital South Texas Veteran Health Care System San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-1651","authenticated-orcid":false,"given":"Amalia","family":"Gastaldelli","sequence":"additional","affiliation":[{"name":"Cardiometabolic Risk Unit CNR Institute of Clinical Physiology Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"D'Alessio","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cincinnati College of Medicine Cincinnati Ohio"},{"name":"Division of Endocrinology Duke University Medical Center Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00073.2012"},{"issue":"20","key":"e_1_2_7_3_1","first-page":"1997","article-title":"Bariatric surgery or intensive medical therapy for diabetes after 5 years","volume":"376","author":"Schauer PR","year":"2017","journal-title":"N Engl J 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C\u2010peptide, and catecholamines","volume":"265","author":"Teff KL","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.5.1030"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.5.801"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.1.R198"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.01.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.3.280"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.3.596"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.86"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118411"}],"container-title":["Diabetes, Obesity and 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