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Insulin therapy is an established treatment for hyperglycaemia and acute hyperkalaemia, and has also been used for myocardial dysfunction resistant to inotropic support. Insulin is commonly used in both organ donors and transplant recipients for hyperglycaemia, but the underlying knowledge base supporting its use remains limited. Insulin therapy plays an important yet poorly understood role in both organ donation and transplantation. Tight glycaemic control has been extensively studied in critical care over the past 15\u2009years; however, this has not yet translated into the field of transplantation, where patients are more unwell and where improved outcomes remain an ongoing challenge. Insulin therapy and optimization of glycaemic control represent important areas for future hypothesis\u2010driven research into organ donation and transplantation, such as amelioration of ischaemia\u2010reperfusion injury, rejection and infection.<\/jats:p>","DOI":"10.1111\/dom.13728","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T05:50:56Z","timestamp":1553838656000},"page":"1521-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Insulin therapy in organ donation and transplantation"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-1053","authenticated-orcid":false,"given":"Iestyn M.","family":"Shapey","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Summers","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Yiannoullou","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bannard\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Critical Care Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Augustine","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Rutter","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Manchester Diabetes Centre Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"van Dellen","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60553-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0883-9441(95)90017-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199608000-00014"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32835c29ef"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182a949fa"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.12.2935"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01879.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.10.005"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.8.6854"},{"key":"e_1_2_12_11_1","unstructured":"Blood and Transplant. 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