{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:54Z","timestamp":1772160114655,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We conducted a 4\u2010week randomized, sham\u2010controlled, single\u2010blind, parallel\u2010group trial to examine the effect of repetitive transcranial magnetic stimulation (rTMS) delivered to the left dorsolateral prefrontal cortex (DLPFC) on functional brain connectivity and body weight in adults with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Of the 45 volunteers with obesity, aged between 18 and 70\u2009years (body mass index [BMI] \u226525\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      according to the obesity criterion for an Asian population), 36 participants (54.1 \u00b1\u200911.0 years, BMI 30.2 \u00b1 3.5 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 77.8% female) completed the 4\u2009weeks of follow\u2010up, undergoing two resting state fMRI scans (20 in the real stimulation group and 16 in the sham stimulation group). A total of eight sessions of high\u2010frequency rTMS targeting the left DLPFC were provided over a period of 4\u2009weeks (5\u2010second trains with 25\u2010second inter\u2010train intervals, 10 Hz, 110% motor threshold; 2000 pulses over 20\u2009minutes).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants in the real stimulation group showed significantly greater weight loss from baseline following the eight session of rTMS (\u22122.53\u2009\u00b1\u20092.41\u2009kg vs 0.38\u2009\u00b1\u20091.13\u2009kg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). For intrinsic brain connectivity comparisons, the between\u2010ness centrality values within the right frontoparietal network tended to increase with rTMS, and a significant interaction effect was identified for time (pre vs post)\u2009\u00d7\u2009rTMS (real vs sham) in the right frontoparietal network (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031, FDR corrected).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed that rTMS selectively increased resting state functional connectivity within the right frontoparietal network. Our findings suggest that high\u2010frequency rTMS to the left DLPFC might strengthen the frontoparietal network that orchestrates top\u2010down inhibitory control to reduce food intake.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13763","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T06:03:03Z","timestamp":1556863383000},"page":"1956-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The effects of high\u2010frequency repetitive transcranial magnetic stimulation on resting\u2010state functional connectivity in obese adults"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-8993","authenticated-orcid":false,"given":"Se\u2010Hong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Family Medicine, St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-337X","authenticated-orcid":false,"given":"Bo\u2010Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Sungkyunkwan University  Suwon Republic of Korea"},{"name":"Center for Neuroscience Imaging Research Institute for Basic Science (IBS)  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoungseob","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Sungkyunkwan University  Suwon Republic of Korea"},{"name":"Center for Neuroscience Imaging Research Institute for Basic Science (IBS)  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjin","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Imaging Research Institute for Basic Science (IBS)  Suwon Republic of Korea"},{"name":"School of Electronic and Electrical Engineering Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngkook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, College of Medicine, Yeouido St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Mi","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Hye","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Uijeongbu St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. 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