{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:12:42Z","timestamp":1790233962720,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003491","name":"Herlev Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether the mineralocorticoid receptor antagonist eplerenone has beneficial effects on liver fat and metabolism in patients with type 2 diabetes (T2D), the mineralocorticoid receptor antagonist in type 2 diabetes (MIRAD) trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      In this 26\u2010week, double\u2010blind, randomized, placebo\u2010controlled trial, we enrolled 140 patients with T2D and high risk of cardiovascular disease. Patients were randomized 1:1 to either eplerenone with a target dose of 200\u2009mg\/day for patients with estimated glomerular filtration rate (eGFR) of 60\u2009mL\/min per 1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      or more and 100\u2009mg\/day for patients with eGFR between 41 and 59\u2009mL\/min per 1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      or placebo. The primary outcome measure was change in liver fat by proton magnetic resonance spectroscopy at week 26 from baseline; secondary outcomes were changes in metabolism, and safety by incident hyperkalaemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No changes in liver fat in the eplerenone group 0.91% (95% CI \u22120.57 to 2.39) or the placebo group \u22121.01% (\u22122.23 to 0.21) were found. The estimated absolute treatment difference was 1.92% (\u22123.81 to 0.01;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.049). There was no beneficial impact on supporting secondary outcome variables of metabolism as fat mass distribution, lipid metabolism or insulin resistance. Despite a high dosage of eplerenone 164 versus 175\u2009mg in patients treated with placebo (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.228), the number of patients with incident hyperkalaemia (\u22655.5 mmol\/L) was low, with six in the eplerenone versus two in the placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.276).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The addition of high doses of eplerenone to background antidiabetic and antihypertensive therapy does not show beneficial effects on liver fat and metabolism in patients with T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13809","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T02:18:40Z","timestamp":1560219520000},"page":"2305-2314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effect of the mineralocorticoid receptor antagonist eplerenone on liver fat and metabolism in patients with type 2 diabetes: A randomized, double\u2010blind, placebo\u2010controlled trial (MIRAD trial)"],"prefix":"10.1111","volume":"21","author":[{"given":"Marie L.","family":"Johansen","sequence":"first","affiliation":[{"name":"Department of Endocrinology\u2010Internal Medicine, Copenhagen University Hospital Herlev\u2010Gentofte Hospital  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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