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There is a high prevalence of cardiovascular disease (CVD) in the region among people with type 2 diabetes mellitus (T2DM) and it is often associated with multiple risk factors including hypertension, renal disease and obesity. The early onset of T2DM and the eventual long disease duration portends an increasing proportion of the population to premature CVD. In addition to lowering blood glucose, sodium\u2010glucose co\u2010transporter\u20102 (SGLT\u20102) inhibitors exert favourable effects on multiple risk factors (including blood pressure, body weight and renal function) and provide an opportunity to reduce the risk of CVD in patients with T2DM. In this article, we consolidated the existing literature on SGLT\u20102 inhibitor use in Asian patients with T2DM and established contemporary guidance for clinicians. We extensively reviewed recommendations from international and regional guidelines, published data from clinical trials in the Asian population (dapagliflozin, canagliflozin, empagliflozin, ipragliflozin, luseogliflozin and tofogliflozin), CVD outcomes trials (EMPAREG\u2010OUTCOME, CANVAS and DECLARE\u2010TIMI 58) and real\u2010world evidence studies (CVD\u2010REAL, EASEL, CVD\u2010REAL 2 and OBSERVE\u20104D). A series of clinical recommendations on the use of SGLT\u20102 inhibitors in Asian patients with T2DM was deliberated among experts with multiple rounds of review and voting. Based on the available evidence, we conclude that SGLT\u20102 inhibitors represent an evidence\u2010based therapeutic option for the primary prevention of heart failure hospitalization and secondary prevention of CVD in patients with T2DM, and should be considered early on in the treatment algorithm for patients with multiple risk factors, or those with established CVD.<\/jats:p>","DOI":"10.1111\/dom.13819","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T05:13:19Z","timestamp":1562044399000},"page":"2354-2367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Use of sodium\u2010glucose co\u2010transporter\u20102 inhibitors in patients with type 2 diabetes mellitus and multiple cardiovascular risk factors: An Asian perspective and expert recommendations"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-7050","authenticated-orcid":false,"given":"Chaicharn","family":"Deerochanawong","sequence":"first","affiliation":[{"name":"Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew P.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Malaya Medical Center  Kuala Lumper Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bien J.","family":"Matawaran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Endocrinology, Diabetes and Metabolism University of Santo Tomas Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8805-8340","authenticated-orcid":false,"given":"Wayne H.\u2010H.","family":"Sheu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen H.","family":"Man","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, FV Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketut","family":"Suastika","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Udayana University, Sanglah General Hospital  Bali Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin M.","family":"Khoo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-2208","authenticated-orcid":false,"given":"Kun\u2010Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6069","authenticated-orcid":false,"given":"Andrea","family":"Luk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambrish","family":"Mithal","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Medicity  Gurgaon India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-1598","authenticated-orcid":false,"given":"Ji","family":"Linong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People's Hospital  Peking China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"WHO. 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