{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:43:24Z","timestamp":1790185404880,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To test the hypothesis that gut hormone glucagon\u2010like peptide\u20102 (GLP\u20102) mobilizes intestinal triglyceride (TG) stores and stimulates chylomicron secretion by a nitric oxide (NO)\u2010dependent mechanism in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a randomized, single\u2010blind, cross\u2010over study, 10 healthy male volunteers ingested a high\u2010fat formula followed, 7 hours later, by one of three treatments: NO synthase inhibitor L\u2010N\n                      <jats:sup>G<\/jats:sup>\n                      \u2010monomethyl arginine acetate (L\u2010NMMA)\u2009+\u2009GLP\u20102 analogue teduglutide, normal saline + teduglutide, or L\u2010NMMA + placebo. TG in plasma and lipoprotein fractions were measured, along with measurement of blood flow in superior mesenteric and coeliac arteries using Doppler ultrasound in six participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Teduglutide rapidly increased mesenteric blood flow and TG concentrations in plasma, in TG\u2010rich lipoproteins, and most robustly in chylomicrons. L\u2010NMMA significantly attenuated teduglutide\u2010induced enhancement of mesenteric blood flow but not TG mobilization and chylomicron secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20102 mobilization of TG stores and stimulation of chylomicron secretion from the small intestine appears to be independent of systemic NO in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13839","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T04:54:07Z","timestamp":1564548847000},"page":"2535-2541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Glucagon\u2010like peptide\u20102 mobilizes lipids from the intestine by a systemic nitric oxide\u2010independent mechanism"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-5689","authenticated-orcid":false,"given":"Changting","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Medicine and Department of Physiology, Division of Endocrinology and Metabolism Banting and Best Diabetes Centre, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priska","family":"Stahel","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Physiology, Division of Endocrinology and Metabolism Banting and Best Diabetes Centre, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Morgantini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Physiology, Division of Endocrinology and Metabolism Banting and Best Diabetes Centre, University of Toronto  Toronto 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