{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:54Z","timestamp":1772160114975,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T00:00:00Z","timestamp":1570924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cases of a rare but serious infection called Fournier's gangrene have been reported with sodium\u2010glucose co\u2010transporter\u20102 inhibitors (SGLT\u20102i). To evaluate the safety signal in a population of patients with type 2 diabetes, we used administrative claims data from Horizon Blue Cross Blue Shield of New Jersey from 2014 through 2017 to estimate incidence rates of Fournier's gangrene or necrotizing fasciitis of the perineum among patients treated with a second\u2010line antidiabetic drug. We found very low incidence rates of Fournier's gangrene or necrotizing fasciitis. While we found no indication of an increased risk among SGLT\u20102i users compared with similar patients treated with other second\u2010line antidiabetic medications, the small number of events yielded wide confidence intervals.<\/jats:p>","DOI":"10.1111\/dom.13886","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T02:08:46Z","timestamp":1569982126000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fournier's gangrene in patients with type 2 diabetes using second\u2010line antidiabetic medications"],"prefix":"10.1111","volume":"22","author":[{"given":"Natalia","family":"Petruski\u2010Ivleva","sequence":"first","affiliation":[{"name":"Science Aetion, Inc  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology Department of Medicine and Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Eapen","sequence":"additional","affiliation":[{"name":"Science Aetion, Inc  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Rajan","sequence":"additional","affiliation":[{"name":"Science Aetion, Inc  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saira","family":"Jan","sequence":"additional","affiliation":[{"name":"Pharmacy Strategy and Clinical Integration Horizon Healthcare Services Inc.  Newark New Jersey"},{"name":"School of Pharmacy Rutgers State University of New Jersey  New Brunswick New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Food and Drug Administration(FDA). Safety Announcement: FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes.2018.https:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm617360.htm. 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