{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:16:16Z","timestamp":1790806576468,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD087023"],"award-info":[{"award-number":["K12HD087023"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Medtronic MiniMed 670G system delivers insulin to patients with type 1 diabetes mellitus (T1DM) using either its hybrid closed\u2010loop (HCL) \u201cAuto Mode\u201d feature or an open\u2010loop mode. In this retrospective, cross\u2010sectional analysis, we quantified the association between time in Auto Mode and both haemoglobin A1c (HbA1c) and time in range (TIR, sensor glucose 70\u2013180\u2009mg\/dL) among 96 paediatric and young adult patients with T1DM. The median percentage time in Auto Mode was 38.5% (interquartile range 0%\u201364%). The percentage time in Auto Mode significantly correlated with HbA1c after adjustment for covariables (\u03b2 = \u22120.008,\n                    <jats:italic>P<\/jats:italic>\n                    =\u20090.014). Each daily 3.4\u2010h increase in Auto Mode time was associated with a 0.1% decrease in HbA1c. Auto Mode time was also correlated with TIR after adjustment for covariables (\u03b2 = 0.14,\n                    <jats:italic>P<\/jats:italic>\n                    =\u20090.02): for each daily 8.6\u2010h increase in Auto Mode time, TIR increased by 5%. While Auto Mode use was low, increased time in Auto Mode was associated with a significantly lower HbA1c and increased TIR. These findings emphasize the importance of identifying strategies to improve the ease of use of HCL systems.\n                  <\/jats:p>","DOI":"10.1111\/dom.13912","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:24:33Z","timestamp":1573431873000},"page":"688-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Increased proportion of time in hybrid closed\u2010loop \u201cAuto Mode\u201d is associated with improved glycaemic control for adolescent and young patients with adult type 1 diabetes using the MiniMed 670G insulin pump"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-2643","authenticated-orcid":false,"given":"Sara H.","family":"Duffus","sequence":"first","affiliation":[{"name":"Ian M. Burr Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics Vanderbilt University School of Medicine  Nashville Tennessee United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain Al","family":"Ta'ani","sequence":"additional","affiliation":[{"name":"Jordan University Hospital  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Slaughter","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University School of Medicine  Nashville Tennessee United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Niswender","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism Vanderbilt University School of Medicine  Nashville Tennessee United States"},{"name":"Veterans Affairs Tennessee Valley Healthcare System  Tennessee United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-0062","authenticated-orcid":false,"given":"Justin M","family":"Gregory","sequence":"additional","affiliation":[{"name":"Ian M. Burr Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics Vanderbilt University School of Medicine  Nashville Tennessee United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1682"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0202"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0421"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0264"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0078"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1093"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"OR14","article-title":"Challenges in implementing hybrid closed loop insulin pump therapy (Medtronic 670G) in a \u2018real world\u2019 clinical setting","volume":"3","author":"Goodwin D","year":"2019","journal-title":"J Endocrinol Soc"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0161"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-5-39"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.13912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.13912","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:40:17Z","timestamp":1761892817000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,9]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/dom.13912"],"URL":"https:\/\/doi.org\/10.1111\/dom.13912","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.13912\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v2\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13912\/v3\/response1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,9]]},"assertion":[{"value":"2019-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}