{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:16Z","timestamp":1787014096659,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to evaluate the newly developed non\u2010invasive blood glucose system NIRLUS\u00ae (Near\u2010Infra Red Light Ultra Sound; NIRLUS Engineering AG, L\u00fcbeck, Germany) under standardized conditions. Seventeen healthy men of normal weight (body mass index 22.4\u2009\u00b1\u20091.4\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), aged 18 to 45\u2009years, were enrolled in this study. During an intravenous glucose tolerance test, blood glucose profiles were measured simultaneously using the NIRLUS system and a \u201cgold standard\u201d laboratory reference system. Correlation analysis revealed a strong association between NIRLUS and reference values (r = 0.934;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Subsequent Bland\u2013Altman analysis showed a symmetric distribution (r = 0.047;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.395), and 95.5% of the NIRLUS\u2013reference pairs were within the difference (d) of d\u2009\u00b1\u20092 SD. The median deviation of all paired NIRLUS\u2013reference values was 0.5\u2009mmol\/L and the mean percent deviation was 11.5%. Error grid analysis showed that 93.6% of NIRLUS\u2013reference pairs are located in the area A, and 6.4% in the area B. No data were allocated in the areas C to E. This proof\u2010of\u2010concept study demonstrates the reproducibility of accurate blood glucose measures obtained by NIRLUS as compared to a gold standard laboratory reference system. The technology of NIRLUS is an important step forward in the development of non\u2010invasive glucose monitoring.\n                  <\/jats:p>","DOI":"10.1111\/dom.13914","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:27:35Z","timestamp":1573432055000},"page":"694-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of a near\u2010infrared light ultrasound system as a non\u2010invasive blood glucose monitoring device"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-7022","authenticated-orcid":false,"given":"Svenja","family":"Meyh\u00f6fer","sequence":"first","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Wilms","sequence":"additional","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Ihling","sequence":"additional","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Windj\u00e4ger","sequence":"additional","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Kalscheuer","sequence":"additional","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Augustinov","sequence":"additional","affiliation":[{"name":"NIRLUS Engineering AG  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Herrmann","sequence":"additional","affiliation":[{"name":"NIRLUS Engineering AG  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Lehnert","sequence":"additional","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian M.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Institute for Endocrinology and Diabetes University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"German Centre for Diabetes Research  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Diabetes [Internet]. World Health Organization.http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes. Accessed August 2 2018."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0108"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805017"},{"key":"e_1_2_7_5_1","unstructured":"EKF Diagnostics Deutschland. Biosen C\u2010Line Glukosemessger\u00e4t Laktatmessger\u00e4t [Internet].https:\/\/www.ekfdiagnostics.de\/produkt\/biosen-glukose-und-laktatmessgerate\/. Accessed February 26 2019."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400932"},{"key":"e_1_2_7_7_1","unstructured":"International Organization for Standardization. ISO 15197:2013 [Internet]. in vitro diagnostic test systems \u2010 Requirements for blood\u2010glucose monitoring systems for self\u2010testing in managing diabetes mellitus.http:\/\/www.iso.org\/cms\/render\/live\/en\/sites\/isoorg\/contents\/data\/standard\/05\/49\/54976.html. 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