{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:55Z","timestamp":1772160115270,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) factorial trial was a landmark randomized controlled clinical trial in 11\u2009140 type 2 diabetic patients from 215 centers in 20 countries with a two\u2010by\u2010two factorial design. In the blood pressure\u2010lowering arm, patients were treated using a fixed combination of the ACE\u2010inhibitor, perindopril, and the thiazide\u2010like diuretic, indapamide, or placebo, whereas in the glucose\u2010lowering arm, the intervention compared the sulphonylurea gliclazide plus other glucose\u2010lowering drugs, targeting a glycated hemoglobin value of 6.5% or less, with standard glucose control. Primary end\u2010points were major macro\u2010 and microvascular events in both arms. This review gives an overview of the results of the primary randomized trial, results from observational follow\u2010up studies, and results of several biomarker studies and discusses the perspectives of these data in the context of recent major outcome trials for current medical treatment.<\/jats:p>","DOI":"10.1111\/dom.13917","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T21:04:56Z","timestamp":1573765496000},"page":"12-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal protection: What have we learnt from ADVANCE about kidney disease in type 2 diabetes?"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-6157","authenticated-orcid":false,"given":"S\u00f8ren T.","family":"Knudsen","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Aarhus (SDCA) Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Diabetes Monash University Central Clinical School  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Diabetes Monash University Central Clinical School  Melbourne VIC Australia"},{"name":"Department of Endocrinology and Diabetes Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100000"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197805182982019"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6343.685"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92462-5"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.703"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808431"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61303-8"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802987"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100612"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.401"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008070667"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62100-0"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60576-4"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0959"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407963"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2322"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.05.002"},{"key":"e_1_2_15_22_1","article-title":"Intensive glucose\u2010lowering and the risk of vascular events and premature death in patients with decreased kidney function: The ADVANCE trial","author":"Ohkuma T","year":"2019","journal-title":"Diabetes Obes Metab"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4473-2"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06200518"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008121270"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602558103"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.383"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2019.1624721"},{"issue":"11","key":"e_1_2_15_29_1","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1681\/ASN.V12112392","article-title":"Loss of tubular bone morphogenetic protein\u20107 in diabetic nephropathy","volume":"12","author":"Wang SN","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0925"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0807625"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13743"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30249-9"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13648"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18269"},{"key":"e_1_2_15_36_1","article-title":"Effect of linagliptin vs glimepiride on major adverse cardiovascular outcomes in patients with type 2 diabetes: the CAROLINA Randomized Clinical Trial","author":"Rosenstock J","year":"2019","journal-title":"JAMA"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0033"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.13917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.13917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:28:25Z","timestamp":1761863305000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":36,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/dom.13917"],"URL":"https:\/\/doi.org\/10.1111\/dom.13917","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.13917\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13917\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"2019-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}