{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:15:22Z","timestamp":1790280922515,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe the real\u2010world prevalence and consequences of hypertriglyceridaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We searched two large patient databases, the National Health and Nutrition Examination Survey (NHANES) database (2007\u20132014) and the Optum Research Database, as well as electronic medical records from two Kaiser Permanente regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The NHANES data showed that ~26% of US adults, including nearly one\u2010third of statin users, had at least borderline hypertriglyceridaemia (triglycerides [TGs] \u22651.69 mmol\/L), and ~40% of adults with diabetes had levels of \u2265150\u2009mg\/dL despite statin use. The Optum analyses demonstrated that those with TG levels \u22651.69 mmol\/L who were on statins had a significantly increased risk of composite initial major cardiovascular (CV) events (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.19\u20131.34;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 vs. patients with TGs &lt;150\u2009mg\/dL). This was accompanied by increased healthcare utilization and direct healthcare costs (HR 1.12, 95% CI 1.08\u20131.16;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the analyses of the Kaiser Permanente records, patients with diabetes and TG levels 2.26\u20135.64 mmol\/L had significantly higher adjusted incidence rates of non\u2010fatal myocardial infarction (rate ratio 1.30, 95% CI 1.08\u20131.58;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006), non\u2010fatal stroke (rate ratio 1.23; 95% CI 1.01\u20131.49;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.037) and coronary revascularization (rate ratio 1.21; 95% CI 1.02\u20131.43;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.027), but not unstable angina (rate ratio 1.33; 95% CI 0.87\u20132.03;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.185) compared with patients with TG levels &lt;1.69 mmol\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010world analyses suggest that elevated TGs are prevalent and commonly associated with increased CV risk. CV outcomes trials in patients with established hypertriglyceridaemia will clarify whether strategies to reduce TG levels can ameliorate residual CV risk in patients taking statins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13921","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T13:44:04Z","timestamp":1574171044000},"page":"279-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Risk of cardiovascular events in patients with hypertriglyceridaemia: A review of real\u2010world evidence"],"prefix":"10.1111","volume":"22","author":[{"given":"Peter P.","family":"Toth","sequence":"first","affiliation":[{"name":"Ciccarone Centre for the Prevention of Cardiovascular Disease Johns Hopkins University School of Medicine  Baltimore Maryland United States"},{"name":"CGH Medical Center  Sterling Illinois United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Fazio","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University  Portland Oregon United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-7324","authenticated-orcid":false,"given":"Nathan D.","family":"Wong","sequence":"additional","affiliation":[{"name":"University of California Irvine School of Medicine  Irvine California United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hull","sequence":"additional","affiliation":[{"name":"Optum  Eden Prairie Minnesota United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7563-6236","authenticated-orcid":false,"given":"Gregory A.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Center for Health Research  Portland Oregon United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990324"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.038"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000173310.85845.7b"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.22.2858"},{"issue":"1","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-2275(20)32331-2","article-title":"Remnant lipoproteins are related to intima\u2010media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides","volume":"42","author":"Karpe F","year":"2001","journal-title":"J Lipid Res"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001282"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.4.203"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.06.057"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00484-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.11.1767"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302689"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.637793"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1026"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182160726"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.04.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308027"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307095"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.866"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13917"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60545-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510926"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507652"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09270"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.784"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2797"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2795"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs431"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003008"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.219881"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht571"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0667-9"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.544"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306249"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01036.2010"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146898.06923.80"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61177-6"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078322"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22370"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0046"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2018.11.008"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2016.0029"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0501"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008740"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.03.028"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1099-z"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00470"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22692"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13537"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.06.029"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.9991"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1609216"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.08.3019"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.047"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.3.309"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.777334"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02047-1"},{"key":"e_1_2_8_59_1","doi-asserted-by":"crossref","unstructured":"LeathermanS FergusonR WeirI et al. Increased residual cardiovascular risk in US veterans and monerately\u2010elevated baseline triglycerides and well\u2010controlled LCL\u2010C levels on statins [abstract].J Am Coll Cardiol. 2019;73(9[suppl 1]):1719.","DOI":"10.1016\/S0735-1097(19)32325-3"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.023"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300955"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070864"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07072-5"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60527-3"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003603"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.948562"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205409"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6273"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203859"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811403"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804989"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812792"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00290.x"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr100396c"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22856"},{"key":"e_1_2_8_76_1","unstructured":"Randomized trial for evaluation in secondary prevention efficacy of combination therapy \u2010 statin and eicosapentaenoic acid UMIN000012069.UMIN Clinical Trials Registry2016.https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr\/ctr.cgi?function=brows&action=brows&recptno=R000014051&type=summary&language=E. Accessed October 9 2019."},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23055"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-14-74"},{"key":"e_1_2_8_79_1","unstructured":"American Diabetes Association\u00ae issues critical updates to the2019standards of medical care in diabetes. 2019.http:\/\/www.diabetes.org\/newsroom\/press-releases\/2019\/ada-issues-critical-updates-to-2019-standards-of-care.html. Accessed: October 9 2019."}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.13921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.13921","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:32:18Z","timestamp":1761870738000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,26]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/dom.13921"],"URL":"https:\/\/doi.org\/10.1111\/dom.13921","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.13921\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v2\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.13921\/v2\/review3","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,26]]},"assertion":[{"value":"2019-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}