{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:57:02Z","timestamp":1791395822957,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["5T32DK063687\u201014"],"award-info":[{"award-number":["5T32DK063687\u201014"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare glycaemic metrics at 3 and 6\u2009months in patients with type 1 diabetes on a 670G hybrid closed\u2010loop (HCL) system after using a sensor\u2010augmented pump (SAP) for at least 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective study from a centre that has the largest number of 670G users in the United States was conducted. Data from 202 SAP users were reviewed. Sixty\u2010one patients were excluded (two for steroid use, four for pregnancy, 27 for previous Enlite use, and 28 for non\u2010continuous use of 670G). Out of 141 patients who met the inclusion criteria, 127 (aged 21\u201368\u2009years) had complete data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HbA1c levels decreased by 0.4% at 3\u2009months and were maintained at 6\u2009months (7.6\u2009\u00b1\u20090.07 vs. 7.2\u2009\u00b1\u20090.08,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.001) with no weight gain at 6\u2009months. Time\u2010in\u2010range (70\u2013180\u2009mg\/dL) increased from 59.5%\u2009\u00b1\u20091.1% to 70.2%\u2009\u00b1\u20091.2% and 70.1%\u2009\u00b1\u20091.1% at 3 and 6\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.001), respectively. At 6\u2009months, time spent in hypoglycaemia (&lt;70\u2009mg\/dL) and time spent in hyperglycaemia (&gt;180\u2009mg\/dL) were reduced by 30% (2.2%\u2009\u00b1\u20090.2% vs. 3.2%\u2009\u00b1\u20090.2%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.05) and 26% (28.3%\u2009\u00b1\u20091.2% vs. 38.1%\u2009\u00b1\u20091.2%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u20090.001), respectively. More time in auto\u2010mode was associated with improved continuous glucose monitoring metrics, lower HbA1c and decreased glycaemic variability. Time in auto\u2010mode declined in men after 3\u2009months, while women maintained similar auto\u2010mode use throughout the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The HCL system improved HbA1c levels and time\u2010in\u2010range, and decreased time spent in hypoglycaemia and hyperglycaemia at 6\u2009months. Auto\u2010mode use was significantly correlated with continuous glucose monitoring metrics and glycaemic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13933","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T17:51:19Z","timestamp":1575309079000},"page":"583-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Long\u2010term real\u2010life glycaemic outcomes with a hybrid closed\u2010loop system compared with sensor\u2010augmented pump therapy in patients with type 1 diabetes"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5179","authenticated-orcid":false,"given":"Halis Kaan","family":"Akturk","sequence":"first","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Giordano","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anagha","family":"Champakanath","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Brackett","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Garg","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Snell\u2010Bergeon","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0078"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0388"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000467"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2017-0099"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0264"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1682"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0421"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11708"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0123"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0515"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0209"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0097"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0242"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0202"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1600"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216851"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-8-52"},{"key":"e_1_2_8_19_1","article-title":"Switching from suspend\u2010before\u2010low insulin pump technology to a hybrid closed loop system improves glucose control and reduces glucose variability: a retrospective observational case\u2010control study [published online ahead of print October 16, 2019]","author":"Lepore G","journal-title":"Diabetes Technol Ther."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0855"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2018.08.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0384"}],"container-title":["Diabetes, Obesity and 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