{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:34:19Z","timestamp":1788813259593,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","award":["NCT02411825"],"award-info":[{"award-number":["NCT02411825"]}],"id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the change in insulin sensitivity, \u03b2\u2010cell function and glucose absorption after 28\u2009days of treatment with high and low doses of SAR425899, a novel dual glucagon\u2010like peptide\u20101 receptor\/glucagon receptor agonist, versus placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Thirty\u2010six overweight to obese subjects with type 2 diabetes were randomized to receive daily subcutaneous administrations of low\u2010dose SAR425899 (0.03, 0.06 and 0.09\u2009mg) and high\u2010dose SAR425899 (0.06, 0.12 and 0.18\u2009mg) or placebo for 28\u2009days; dose escalation occurred after days 7 and 14. Mixed meal tolerance tests were conducted before treatment (day \u22121) and on days 1 and 28. Oral glucose and C\u2010peptide minimal models were used to quantify metabolic indices of insulin sensitivity, \u03b2\u2010cell responsiveness and glucose absorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With low\u2010dose SAR425899, high\u2010dose SAR425899 and placebo, \u03b2\u2010cell function from day \u22121 to day 28 increased by 163%, 95% and 23%, respectively. The change in area under the curve for the rate of meal glucose appearance between 0 and 120\u2009minutes was \u221232%, \u221220% and 8%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After 28\u2009days of treatment, SAR425899 improved postprandial glucose control by significantly enhancing \u03b2\u2010cell function and slowing glucose absorption rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13939","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T20:43:45Z","timestamp":1575578625000},"page":"640-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Dual glucagon\u2010like peptide\u20101 receptor\/glucagon receptor agonist SAR425899 improves beta\u2010cell function in type 2 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