{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:56:11Z","timestamp":1792173371738,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effect of sitagliptin (SITA) and metformin (MET) monotherapy as well as in combination (MET+SITA) on beta\u2010cell function and insulin sensitivity in women with recent gestational diabetes (GDM) and impaired glucose regulation (IGR: impaired fasting glucose and\/or impaired glucose tolerance).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Forty women were randomly assigned to receive SITA (100\u2009mg qd), MET (850\u2009mg bid) or MET+SITA (50\u2009+\u2009850\u2009mg bid) for 16\u2009weeks. A 75\u2009g oral glucose tolerance test (OGTT) and\u2009+125\u2009mg\/dL hyperglycaemic clamp followed by 5\u2009g i.v. L\u2010arginine were performed at baseline and end of study. The primary outcome of the study was the mean change in arginine\u2010stimulated insulin secretion rate during the hyperglycaemic clamp test from baseline to 16\u2010week therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 16, body mass index declined in all groups (\u22121.2\u2009\u00b1\u20090.2\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). MET+SITA gave a greater increase of first phase\n                      <jats:sub>(2\u201310 min)<\/jats:sub>\n                      insulin secretion and arginine\u2010stimulated response (720.3\u2009\u00b1\u2009299.0 to 995.5\u2009\u00b1\u2009370.3\u2009pmol\/L and 3.2\u2009\u00b1\u20090.6 to 4.8\u2009\u00b1\u20091.0 pmoL\/min, respectively, both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) compared with MET and SITA. Similarly, MET+SITA was more effective in increasing OGTT\u2010based glucose sensitivity (55.7\u2009\u00b1\u200911.3 to 108\u2009\u00b1\u200956.2\u2009pmol x min\n                      <jats:sup>\u22121<\/jats:sup>\n                      m\n                      <jats:sup>\u22122<\/jats:sup>\n                      x mM\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04) and insulin\u2010stimulated glucose disposal (M\/I: 2.2\u2009\u00b1\u20090.5 to 4.6\u2009\u00b1\u20091.3\u2009mg\/kg\/min\u00f7\u03bcIU\/min\/ml;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04; Matsuda index [SI]: 3.1\u2009\u00b1\u20090.4 to 5.7\u2009\u00b1\u20091.1;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03) compared with either MET or SITA. Disposition index (ISSI\u20102) increased with MET+SITA and SITA (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), while no significant change was observed in MET. Among MET+SITA women, 33% reverted to normal glucose tolerance (NGT) compared with 14% with MET and 7% with SITA (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that MET+SITA is superior to SITA and MET monotherapy regarding beta\u2010cell function and insulin sensitivity improvement in IGR women with previous GDM, and may offer a potential pharmacologic intervention to reduce the risk of type 2 diabetes in this high\u2010risk population.<\/jats:p>\n                  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