{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:02:45Z","timestamp":1790211765246,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Insulin is routinely used to manage hyperglycaemia in organ donors and during the peri\u2010transplant period in islet transplant recipients. However, it is unknown whether donor insulin use (DIU) predicts beta\u2010cell dysfunction after islet transplantation. We reviewed data from the UK Transplant Registry and the UK Islet Transplant Consortium; all first\u2010time transplants during 2008\u20102016 were included. Linear regression models determined associations between DIU, median and coefficient of variation (CV) peri\u2010transplant glucose levels and 3\u2010month islet graft function. In 91 islet cell transplant recipients, DIU was associated with lower islet function assessed by BETA\u20102 scores (\u03b2 [SE] \u20103.5 [1.5],\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.02), higher 3\u2010month post\u2010transplant HbA1c levels (5.4 [2.6] mmol\/mol,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.04) and lower fasting C\u2010peptide levels (\u2212107.9 [46.1] pmol\/l,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.02). Glucose at 10 512 time points was recorded during the first 5\u2009days peri\u2010transplant: the median (IQR) daily glucose level was 7.9 (7.0\u20108.9) mmol\/L and glucose CV was 28% (21%\u201035%). Neither median glucose levels nor glucose CV predicted outcomes post\u2010transplantation. Data on DIU predicts beta\u2010cell dysfunction 3 months after islet transplantation and could help improve donor selection and transplant outcomes.\n                  <\/jats:p>","DOI":"10.1111\/dom.14088","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T23:23:20Z","timestamp":1590449000000},"page":"1874-1879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Donor insulin use predicts beta\u2010cell function after islet transplantation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-1053","authenticated-orcid":false,"given":"Iestyn M.","family":"Shapey","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Summers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Yiannoullou","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Khambalia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fullwood","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Department of Research and Innovation (medical statistics) Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Hanley","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Casey","sequence":"additional","affiliation":[{"name":"Transplant Unit Royal Infirmary of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shareen","family":"Forbes","sequence":"additional","affiliation":[{"name":"Transplant Unit Royal Infirmary of Edinburgh  Edinburgh UK"},{"name":"Endocrinology Unit University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Diabetes Unit Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul RV","family":"Johnson","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Diabetes Research Group King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bushnell","sequence":"additional","affiliation":[{"name":"Richard Bright Renal Unit Southmead Hospital  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A. M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Augustine","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Rutter","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"van Dellen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Biology and Health University of Manchester  Manchester UK"},{"name":"Department of Renal and Pancreatic Transplantation Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Department of Research and Innovation (medical statistics) Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061267"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30078-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199604150-00010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000172216.47547.d5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181c478fd"},{"key":"e_1_2_10_7_1","unstructured":"Transplant NB and Donation after Brainstem Death (DBD) Donor Optimisation Extended Care Bundle. 2012. Available at:http:\/\/www.odt.nhs.uk\/pdf\/dbd_care_bundle.pdf. Accessed May 13 2017."},{"key":"e_1_2_10_8_1","article-title":"National standards for organ retrieval from deceased donors. Version 2.6","author":"Zalewska K","year":"2013","journal-title":"NHS Blood Transplant"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13807"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02131.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199308000-00022"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.12.2935"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/19382014.2017.1283083"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2007.00272.x"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.14088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.14088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.14088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.14088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:11:28Z","timestamp":1761883888000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.14088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,14]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/dom.14088"],"URL":"https:\/\/doi.org\/10.1111\/dom.14088","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.14088\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14088\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14088\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.14088\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,14]]},"assertion":[{"value":"2020-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}