{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:00Z","timestamp":1772160120091,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To conduct an overall safety assessment of sodium\u2010glucose co\u2010transporter\u20102 (SGLT\u20102) inhibitors used for the treatment of patients with type 1 diabetes (T1D), including ketoacidosis, genital infection, volume depletion, liver and kidney injury events, cardiovascular events, diarrhea and severe hypoglycaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We searched three databases (Pubmed, Embase and the Cochrane Library) for randomized controlled trials that treated T1D by using SGLT\u20102 inhibitors from 2000 to 5 March 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 1653 articles identified that fit our search criteria, 22 studies included qualitative\u2010based results, eight of which were randomized clinical trials that included quantitative\u2010based results. Compared with the control group, the SGLT\u20102 inhibitors treatment group was found to have had an increased incidence of ketoacidosis (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.00001, OR 4.34, 95% CI [2.37, 7.96], I\n                      <jats:sup>2<\/jats:sup>\n                      =\u200918%), events leading to discontinuation (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.0001, OR 1.76, 95% CI [1.34, 2.31], I\n                      <jats:sup>2<\/jats:sup>\n                      =\u20090%), genital infection (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.00001, OR 3.64, 95% CI [2.82, 4.70], I\n                      <jats:sup>2<\/jats:sup>\n                      =\u20090%), volume depletion (\n                      <jats:italic>P<\/jats:italic>\n                      =\u2009.006, OR 2.10, 95% CI [1.23, 3.59], I\n                      <jats:sup>2<\/jats:sup>\n                      =\u20094%) and diarrhoea (\n                      <jats:italic>P<\/jats:italic>\n                      =\u2009.008, OR 1.64, 95% CI [1.14, 2.36], I\n                      <jats:sup>2<\/jats:sup>\n                      =\u20090%). However, according to subgroup analysis, the risk of diarrhoea was dose\u2010related. The incidence of urinary tract infection, cardiovascular events, renal events, liver injury and fracture was not significantly different for the treatment group compared with the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite showing some promise as a treatment approach, the application of SGLT\u20102 inhibitors for patients with T1D should be considered with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14092","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T06:45:13Z","timestamp":1590043513000},"page":"1767-1776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the safety of sodium\u2010glucose co\u2010transporter\u20102 inhibitors for treating patients with type 1 diabetes"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-2793","authenticated-orcid":false,"given":"Weihao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Graduate School of Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobei","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Graduate School of Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"International Diabetes Federation Diabetes Atlas, English Edition 2017","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2441"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X162746"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0789-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44128"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13260"},{"key":"e_1_2_8_9_1","volume-title":"Cochrane handbook for systematic reviews of interventions[M]","year":"2019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_11_1","first-page":"323","article-title":"Bias in meta\u2010analysis and funnel plot","volume":"68","author":"Biljana M","year":"1999","journal-title":"Medical Informatics Europe'99. 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