{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:44:00Z","timestamp":1784547840856,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effects of vitamin D on transient elastography (TE, FibroScan) indices of liver steatosis (controlled attenuation parameter [CAP]) and fibrosis (liver stiffness measurement [LSM]) in adults with non\u2010alcoholic fatty liver disease (NAFLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In this randomized (2:1), double\u2010blind, single\u2010centre, 12\u2010month trial, patients with NAFLD were treated with vitamin D (1000\u2009IU\/day) (n = 201) or a matching placebo (n = 110). Two co\u2010primary outcomes were changes in CAP and LSM after 360\u2009days of treatment versus baseline. Two main secondary outcomes were CAP\/LSM changes after 180\u2009days of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both CAP and LSM gradually decreased in vitamin D\u2010treated patients and slightly increased in the placebo arm. Vitamin D was superior to placebo for both primary outcomes (mean differences in CAP and LSM changes (\u221249.5 dB\/m [95% CI \u221259.5 to \u221239.4] and \u22120.72\u2009kPa [95% CI \u22121.43 to 0.00], respectively) and both secondary outcomes (\u221222.1 dB\/m [\u221232.1 to \u221212.1] and \u22120.89\u2009kPa [\u22121.61 to \u22120.17], respectively). Of a number of exploratory outcomes (change at 12\u2009months vs. baseline), vitamin D reduced serum uric acid (\u221217.9 \u03bcmol\/L [\u221230.6 to \u22125.2]), gamma\u2010glutamyltransferase (\u22128.9 IU\/L [\u221215.5 to \u22122.3)] and fasting serum insulin levels (\u22125.1 pmol\/L [\u22129.3 to \u22120.8]) as well as the homeostatic model assessment of insulin resistance index (\u22121.6 [\u22123.1 to \u22120.2]) (false discovery rate [5%]\u2010adjusted\n                      <jats:italic>P<\/jats:italic>\n                      \u2010values between .0572 and .0952).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low\u2010medium dose supplementation of vitamin D (1000\u2009IU\/day) over 12\u2009months reduces TE indices of liver steatosis (CAP) and fibrosis (LSM) in NAFLD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14129","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T02:45:51Z","timestamp":1593657951000},"page":"2097-2106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Vitamin D for treatment of non\u2010alcoholic fatty liver disease detected by transient elastography: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Vesna","family":"Lukenda Zanko","sequence":"first","affiliation":[{"name":"Department of Internal Medicine General Hospital \"Josip Ben\u010devi\u0107\"  Slavonski Brod Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Domislovic","sequence":"additional","affiliation":[{"name":"Department for Gastroenterology and Hepatology University Hospital Center Zagreb  Zagreb 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