{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:02Z","timestamp":1772160122250,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinicians frequently monitor serum C\u2010reactive protein (CRP) levels during therapy for diabetic foot infections (DFIs), but evidence supporting this is unclear. Using a database from prospective controlled DFI trials, with fixed duration of antibiotic therapy, we correlated the CRP levels at study enrolment and at end of therapy (EOT). Among 159 DFI episodes, 93 involved the bone and 66 the soft tissues. Overall, treatment cured 122 infections (77%), while 37 episodes (23%) recurred after a median of 53\u2009days. The median CRP in the groups with cure versus failure differed minimally at enrolment (median 67 vs. 81\u2009mg\/L) or EOT (7 vs. 10\u2009mg\/L). Similarly, there was negligible difference in the percentage of CRP levels that normalized at EOT (39% vs. 35%). In our prospective cohorts, a blunt iterative monitoring of CRP during DFI treatment, without correlation with clinical findings, failed to predict treatment failures.<\/jats:p>","DOI":"10.1111\/dom.14222","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T11:18:56Z","timestamp":1602069536000},"page":"637-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Is routine measurement of the serum\n                    <scp>C\u2010reactive<\/scp>\n                    protein level helpful during antibiotic therapy for diabetic foot infection?"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-7080","authenticated-orcid":false,"given":"Truong\u2010Thanh","family":"Pham","sequence":"first","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"},{"name":"Orthopedic Surgery Service Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Balgrist University Hospital  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Gariani","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Kressmann","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases Geneva University Hospitals  Geneva Switzerland"},{"name":"Orthopedic Surgery Service Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois R.","family":"Jornayvaz","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetes, 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734613486152"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12545"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000530"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3281"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"13124","DOI":"10.4414\/smw.2010.13124","article-title":"Postoperative serum pro\u2010calcitonin and C\u2010reactive protein levels in patients with orthopedic infections","volume":"140","author":"U\u00e7kay I","year":"2010","journal-title":"Swiss Med 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