{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:03Z","timestamp":1772160123492,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effects of dapagliflozin, metformin and exercise treatment on changes in plasma glucagon concentrations in individuals with overweight and HbA1c\u2010defined prediabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      One\u2010hundred and twenty individuals with overweight (body mass index \u2265\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and prediabetes (HbA1c of 39\u201047\u2009mmol\/mol) were randomized to a 13\u2010week intervention with dapagliflozin (10 mg once daily), metformin (850\u2009mg twice daily), exercise (30\u2009minutes of interval training 5\u2009days per week) or control (habitual living). A 75\u2010g oral glucose tolerance test (OGTT) (0, 30, 60 and 120\u2009minutes) was administered at baseline, at 13\u2009weeks (end of intervention) and at 26\u2009weeks (end of follow\u2010up). Linear mixed effects models with participant\u2010specific random intercepts were used to investigate associations of the interventions with fasting plasma glucagon concentration, insulin\/glucagon ratio and glucagon suppression during the OGTT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, the median (Q1; Q3) age was 62 (54; 68) years, median fasting plasma glucagon concentration was 11 (7; 15) pmol\/L, mean (SD) HbA1c was 40.9 (2.3) mmol\/mol and 56% were women. Compared with the control group, fasting glucagon did not change in any of the groups from baseline to the end of the intervention (dapagliflozin group: \u22125% [95% CI: \u221229; 26]; exercise group: \u22128% [95% CI: \u221231; 24]; metformin group: \u22122% [95% CI: \u221227; 30]). Likewise, there were no differences in insulin\/glucagon ratio and glucagon suppression during the OGTT between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In individuals with prediabetes, 13\u2009weeks of treatment with dapagliflozin, metformin or exercise was not associated with changes in fasting or post\u2010OGTT glucagon concentrations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14246","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T12:47:04Z","timestamp":1604494024000},"page":"530-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["No effects of dapagliflozin, metformin or exercise on plasma glucagon concentrations in individuals with prediabetes: A post hoc analysis from the randomized controlled\n                    <scp>PRE\u2010D<\/scp>\n                    trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-1945","authenticated-orcid":false,"given":"Kim K. B.","family":"Clemmensen","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-1560","authenticated-orcid":false,"given":"Martin B.","family":"Blond","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-4960","authenticated-orcid":false,"given":"Hanan","family":"Amadid","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-765X","authenticated-orcid":false,"given":"Lea","family":"Bruhn","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5045-5351","authenticated-orcid":false,"given":"Dorte","family":"Vistisen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-4199","authenticated-orcid":false,"given":"Kristian","family":"Karstoft","sequence":"additional","affiliation":[{"name":"The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Pharmacology, Bispebjerg\u2010Frederiksberg Hospital University of Copenhagen  Copenhagen 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Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-5753","authenticated-orcid":false,"given":"Nicolai J.","family":"Wewer Albrechtsen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry University of Copenhagen, Rigshospitalet  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-0252","authenticated-orcid":false,"given":"Signe S.","family":"Torekov","sequence":"additional","affiliation":[{"name":"NNF Center for Basic Metabolic Research University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen  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