{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:03Z","timestamp":1772160123719,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We validated the effect of linagliptin, an oral dipeptidyl peptidase\u20104 inhibitor, on nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). A total of 50 patients with NAFLD and T2DM treated with metformin were randomized (1:1) to metformin plus add\u2010on linagliptin (linagliptin group) or to an increased dose of metformin (metformin group) for 52\u2009weeks. The primary endpoint was change in hepatic steatosis from baseline to week 52 as quantified by unenhanced computed tomography imaging. Secondary endpoints included changes in the levels of anthropometric, biochemical and adipokinetic markers. The linagliptin group showed no statistically significant reduction in hepatic steatosis as compared to the metformin group (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.97), although changes in hepatic steatosis were significantly correlated with decreased liver enzymes in both groups. Body weight was significantly reduced in the metformin group but not in the linagliptin group (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.002). Serum leptin levels were significantly increased in the linagliptin group compared to the metformin group (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.003), and were correlated with the changes body weight in whole samples. Adverse events were not different between the two groups (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.78). Add\u2010on linagliptin demonstrated a safe profile but was not superior to increased metformin in reducing hepatic steatosis.\n                  <\/jats:p>","DOI":"10.1111\/dom.14263","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T06:18:49Z","timestamp":1606285129000},"page":"832-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metformin dose increase versus added linagliptin in non\u2010alcoholic fatty liver disease and type 2 diabetes: An analysis of the\n                    <scp>J\u2010LINK<\/scp>\n                    study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-8697","authenticated-orcid":false,"given":"Yasuji","family":"Komorizono","sequence":"first","affiliation":[{"name":"Department of Hepatology Nanpuh Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Hosoyamada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kagoshima Kouseiren Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Jiaikai Clinic  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Kajiya","sequence":"additional","affiliation":[{"name":"Uenomachi\u2010Kajiya Clinic  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Tempozan Naika Medical Clinic  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Ueyama","sequence":"additional","affiliation":[{"name":"Ueyama Clinic  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Shinmaki","sequence":"additional","affiliation":[{"name":"Shinmaki Clinic  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Koriyama","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology National Hospital Organization, Kagoshima Medical Center  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Tsukasa","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Nanpuh Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Kamada","sequence":"additional","affiliation":[{"name":"Center of Diabetes Idzuro\u2010Imamura Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3952-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.154001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102863"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308445"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.0284"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/11630900-000000000-00000"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-013-0053-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i19.534"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30320"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.021"},{"issue":"3","key":"e_1_2_9_13_1","first-page":"729","article-title":"Increased hepatic expression of dipeptidyl peptidase\u20104 in non\u2010alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism","volume":"5","author":"Miyazaki M","year":"2012","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170587"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2018.33.1.33"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3769-3"}],"container-title":["Diabetes, Obesity and 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