{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:55:46Z","timestamp":1792007746226,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014603","name":"Orexigen Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014603","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sustained weight loss improves liver histology in non\u2010alcoholic fatty liver disease. This post hoc analysis of four phase III, 56\u2010week, randomized controlled trials investigated if extended\u2010release naltrexone and bupropion (NB) affects alanine aminotransferase (ALT) and Fibrosis\u20104 (FIB\u20104) index in adults with overweight or obesity. Two thousand and seventy\u2010three subjects (NB = 1310; placebo = 763; 79.0% female; 81.6% Caucasian) had baseline mean weight 101\u2009kg, body mass index 36.2 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , ALT 26.9 IU\/L and FIB\u20104 0.79. At 56\u2009weeks, NB\u2010treated subjects experienced more weight loss than placebo (8.7 vs. 3.2\u2009kg, respectively,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.0001). Weight loss, independent of treatment, was associated with improved ALT and FIB\u20104 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.0001). There was a significant independent effect of NB on change from baseline for FIB\u20104 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.0001), but not for ALT (\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.54). Categorical ALT response (from above to within normal ranges: 10\u201040\u2009IU\/L for men; 7\u201035\u2009IU\/L for women) and achievement of 25% and 50% reduction in ALT were greater for NB versus placebo, and independently affected by weight loss (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.0001), but not treatment. NB\u2010associated weight loss may improve liver health by normalizing ALT values for those with high baseline levels.\n                  <\/jats:p>","DOI":"10.1111\/dom.14284","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T08:51:05Z","timestamp":1607071865000},"page":"861-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Extended\u2010release naltrexone\/bupropion and liver health: Pooled, post hoc analysis from four randomized controlled trials"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1461-1465","authenticated-orcid":false,"given":"Harpreet S.","family":"Bajaj","sequence":"first","affiliation":[{"name":"LMC Diabetes and Endocrinology  Brampton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melonie","family":"Burrows","sequence":"additional","affiliation":[{"name":"Bausch Health  Laval Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Blavignac","sequence":"additional","affiliation":[{"name":"Bausch Health  Laval Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Paron","sequence":"additional","affiliation":[{"name":"Bausch Health  Laval Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Camacho","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Sciences University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol","family":"Gould","sequence":"additional","affiliation":[{"name":"Currax Pharmaceuticals LLC  Morristown New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Barakat","sequence":"additional","affiliation":[{"name":"Bausch Health  Laval Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.07.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.09.150"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.08.039"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05694.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1691-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"90","article-title":"Efficacy of orlistat in non\u2010alcoholic fatty liver disease: a systematic review and meta\u2010analysis","volume":"9","author":"Wang H","year":"2018","journal-title":"Biomed 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