{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:04Z","timestamp":1772160124124,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To estimate the proportion of individuals with type 2 diabetes mellitus (T2DM) undergoing changes in glucose\u2010lowering therapy in 2019 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Individuals with T2DM who had at least one consultation in one of 940 general (including diabetologist) practices in Germany between January and July 2019 (N = 79\u2009268) and between January and July 2020 (N = 85\u2009046) were included. Therapy changes were defined as the prescription of new glucose\u2010lowering drugs, with or without the discontinuation of previous treatments (therapy switch and add\u2010on therapy, respectively). The number of T2DM patients with at least one medication regimen change was calculated for the periods 1 January to 14 March in 2019 and 2020, and for the periods 15 March to 31 July in 2019 and 2020. March 2020 corresponded to the beginning of the lockdown in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, there was a decrease in the number of patients with at least one medication regimen change in the period 15 March to 31 July 2019 compared with 15 March to 31 July 2020 (dipeptidyl peptidase\u20104 inhibitors: \u221215%; sodium\u2010glucose co\u2010transporter\u20102 inhibitors: \u22123%; glucagon\u2010like peptide\u20101 receptor agonists: 0%; other oral glucose\u2010lowering drugs: \u22126%; and insulin: \u221221%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The coronavirus disease\u20102019 (COVID\u20102019) pandemic had a strong impact on glucose\u2010lowering drug use in T2DM patients in Germany. More research is warranted to further investigate the treatment and management of T2DM individuals during the COVID\u201019 era in Germany and elsewhere.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14293","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T14:37:05Z","timestamp":1608043025000},"page":"910-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Change in glucose\u2010lowering medication regimens in individuals with type 2 diabetes mellitus during the COVID\u201019 pandemic in Germany"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-1239","authenticated-orcid":false,"given":"Louis","family":"Jacob","sequence":"first","affiliation":[{"name":"Research and Development Unit Parc Sanitari Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Faculty of Medicine University of Versailles Saint\u2010Quentin\u2010en\u2010Yvelines  Montigny\u2010le\u2010Bretonneux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Rickwood","sequence":"additional","affiliation":[{"name":"IQVIA  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Rathmann","sequence":"additional","affiliation":[{"name":"German Diabetes Center Institute for Biometrics and Epidemiology  Duesseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7227","authenticated-orcid":false,"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[{"name":"Epidemiology IQVIA  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.45053"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41256-020-00135-6"},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization.WHO coronavirus disease (COVID\u201019) dashboard 2020.https:\/\/covid19.who.int\/"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-209004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/epa2.1091"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2020.05.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2020-0048"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01183-6"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"Gout management and outcomes during the COVID\u201019 pandemic: a cross\u2010sectional internet survey","volume":"12","author":"Singh JA","year":"2020","journal-title":"Therap Adv Musculoskelet Dis"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.07.051"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.10.005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.06.042"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.03.014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.08.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.08.012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.04.053"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.10.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.10.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13410-020-00880-x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.09.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2020.107748"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.05.035"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01512.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP203320"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6936a4"},{"key":"e_1_2_8_27_1","unstructured":"Euronews.Coronavirus: Germany to begin a \u201clockdown light\u201d from November 2 says Angela Merkel.Euronews.2020.https:\/\/www.euronews.com\/2020\/10\/28\/germany-to-begin-partial-lockdown-from-november-2-says-angela-merkel. 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