{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:21:47Z","timestamp":1788315707211,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the safety, pharmacokinetics and pharmacodynamics of ADO09 with insulin lispro (Lispro) and separate subcutaneous injections of human insulin and pramlintide (Ins&amp;Pram) in 24 subjects with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>At three dosing visits, participants received single doses of ADO09, Ins&amp;Pram or Lispro immediately before eating a standardized mixed meal together with 1 g of acetaminophen, which was used as a surrogate marker to evaluate the kinetics of gastric emptying. Premeal blood glucose was adjusted to 126\u2009mg\/dL\u2009\u00b1\u200910% by means of insulin and glucose infusions. The insulin dose was 7.5 U and the pramlintide dose was 45\u2009\u03bcg. Blood glucose, glucagon and acetaminophen concentrations were assessed as pharmacodynamic endpoints; insulin and pramlintide concentrations were analysed as pharmacokinetic endpoints, and safety and tolerability were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with Lispro, ADO09 reduced postprandial blood glucose (ppBG) excursions by more than 95% in the first hour postmeal (mean\u2009\u00b1\u2009SD \u2206AUC BG 0\u20101 h: 1.4\u2009\u00b1\u20099.9 mg*h\/dL vs. 43.5\u2009\u00b1\u200915.3 mg*h\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Maximum ppBG was significantly improved with ADO09 (\u2206BGmax 87.0\u2009\u00b1\u200935.5 mg\/dL) versus both Lispro (109.2\u2009\u00b1\u200931.1 mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      = .0133) and Ins&amp;Pram (109.4\u2009\u00b1\u200944.3 mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      = .0357). Gastric emptying with ADO09 was similar to Ins&amp;Pram and significantly slower than with Lispro. All treatments were well tolerated and both adverse events and hypoglycaemic events were rare during the meal test procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ADO09 was well tolerated and markedly reduced ppBG compared with Lispro. ADO09 formulation was generally similar to the separate administration of insulin and pramlintide, except for a better BG level in the 4\u20108 h interval postmeal. These positive results warrant further investigations with ADO09.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.14302","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T13:15:58Z","timestamp":1608297358000},"page":"961-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["ADO09, a co\u2010formulation of the amylin analogue pramlintide and the insulin analogue A21G, lowers postprandial blood glucose versus insulin lispro in type 1 diabetes"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-7165","authenticated-orcid":false,"given":"Grit","family":"Andersen","sequence":"first","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Meiffren","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Famulla","sequence":"additional","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-2037","authenticated-orcid":false,"given":"Tim","family":"Heise","sequence":"additional","affiliation":[{"name":"Profil  Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Ranson","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Seroussi","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosy","family":"Eloy","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gaudier","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Charvet","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Ping","family":"Chan","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Soula","sequence":"additional","affiliation":[{"name":"Adocia  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9196-9906","authenticated-orcid":false,"given":"J. 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